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In this article, we investigate a diffusive two-strain epidemic model with non-monotone incidence rate and virus mutation. The positivity, existence and uniform boundedness of the solutions of the model system are studied. It is found that the system has three equilibrium points, namely the infection-free equilibrium point, the strain-2 endemic equilibrium point and both the strain-1 and strain-2 endemic equilibrium points. The global asymptotic stability analysis of the diffusive model system near all the equilibrium points is carried out by constructing appropriate Lyapunov functional. It is found that the system has no strain-1 endemic equilibrium point possibly due to the virus mutation. So, in this type of diseases, the infection due to strain-1 cannot be persistent in the community.

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