In spite of decades of malaria research and clinical trials, a fully effective and long-lasting preventive vaccine remains elusive. In the present study, 5370 proteins of genome were screened for the presence of signal peptide/anchor and GPI anchor motifs. Out of 45 screened surface-associated proteins, 22 were consensually predicted as antigens and had no orthologs in human and mouse except circumsporozoite protein (PF3D7_0304600). Among 22 proteins, 19 were identified as new antigens. In the next step, a total of 4944 peptides were predicted as CD8+ T cell epitopes from 22 probable antigens. Of these, the highest scoring 262 epitopes from each antigen were taken for optimization study in the malaria-endemic regions which covered a broad human population (~93.95%). The predicted epitope 13ILFYFFLWV21 of antigen 6-cysteine (PF3D7_1346800) was binding to the HLA-A*0201 allele with the highest fraction (26%) of immunogenicity in the target populations of North-East Asia, South-East Asia, and sub-Saharan Africa. Therefore, these epitopes are proposed to be favored in vaccine designs against malaria.

Background. Cancer survivors must manage a range of adverse symptoms and side effects postdiagnosis. These effects often co-occur with preexisting comorbid conditions. Recognizing the complex chronicity of the disease, self-management support interventions have been developed to promote cancer survivors’ knowledge, skills, and confidence to self-manage their health. Though shown to be beneficial, the processes underlying self-management have yet to be explicated. Aim. To explore how a community-based self-management support intervention fosters cancer survivors’ knowledge, confidence, and skills to self-manage their health. Method. A qualitative case study adopting multiple viewpoints was utilized. Seventeen cancer survivors who participated in a self-management support intervention (referred to as a cancer coaching program) were interviewed and six program staff took part in a focus group. Transcripts from the interviews and focus group were analyzed using a hybrid inductive–deductive approach guided by principles of qualitative description. Results. Cancer survivors and program staff offered complementary perspectives that enhanced our understanding of how the self-management support intervention fosters cancer survivors’ knowledge, confidence, and skills to self-manage their health. Four themes captured strategies necessary to promote self-management: (1) looking beyond the disease: the importance of holistic person-centered care, (2) cocreating plans: the key to effective and meaningful self-management support, (3) fostering activation via tailored, targeted, and expert-sourced information and resources, and (4) having dependable and impartial emotional support. Within each theme, pertinent self-management support strategies were described by cancer survivors and program staff. Discussion and Conclusion. Findings offer an understanding of how one community-based self-management support intervention promotes self-management and highlight valuable self-management support strategies that could be incorporated into existing and future interventions.

The Aishwariya Oil Field located in Barmer Basin of Rajasthan India having STOIIP of ∼300 MMBBLS was initially developed with down-dip edge water injection. The main reservoir unit, Fatehgarh Formation, has excellent reservoir characteristics with porosities of 20-30% and permeability of 1 to 5 Darcys. The Fatehgarh Formation is subdivided into Lower Fatehgarh (LF) and Upper Fatehgarh (UF) Formations, of which LF sands are more homogenous and have slightly better reservoir properties. The oil has in-situ viscosity of 10-30 cP. Given its adverse waterflood mobility ratio, the importance of EOR was recognised very early. Initial screening studies identified that chemical EOR (polymer and ASP) was preferred choice of EOR process. Extensive lab studies and simulation work was conducted to develop the polymer flood concept. A polymer flood development plan was prepared targeting the LF sands of the field utilizing the lessons learnt from nearby Mangala Field polymer implementation project. The polymer flood in Aishwariya Field was implemented in two stages. In the first stage, a polymer injectivity test was conducted in 3 wells to establish the potential for polymer injection in these wells. The injection was extended to 3 more wells and continued for ∼4 years. Significant water cut drop was observed in nearby wells during this phase of polymer injection. In the next stage, polymer flooding was extended to the entire LF sands with drilling of 14 new infill wells and conversion of 8 existing wells to polymer injectors. A ∼14 km long pipeline was laid from the Mangala Central Polymer Facility to well pads in the field to cater to the requirement of 6-8 KBPD of ∼15000 ppm polymer mother solution. The philosophy of pre-production for extended periods was considered prior to start of polymer injection for all wells as it significantly improved injection (reduced skin) and conformance. Full field polymer flood project was implemented, and injection was ramped up to the planned 40-50 KBPD of polymerized water within a month owing to good injectivity and polymer solution quality. A detailed laboratory, well and reservoir surveillance program has been implemented and the desired wellhead viscosity of 25-30 cP has been achieved. Initial response shows significant increase in oil production rate and decrease in water-cut. This paper presents the polymer laboratory studies, initial long term injectivity test results, polymer flood development concept and planning, simulation studies and field implementation in LF Formation in Aishwariya Field.