Synthesis of N-(1H -benzimidazol-2-yl)-6-substituted-1,3-benzothiazol-2-amines and 6-substituted-N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-benzothiazol-2-amines by the reaction of substituted 2-aminobenzothiazoles with carbon disulphide and methyl iodide followed by the reaction with o-phenylene diamine/ethylene diamine are reported. All the synthesized compounds were characterized by elemental analysis, IR spectra and 1 H NMR spectral studies. The potent antibacterial and entomological (antifeedant, acaricidal, contact toxicity and stomach toxicity) activities of the synthesized compounds were investigated.

A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl) hexahydro-1,3,5-triazine derivatives (3) have been synthesized by condensation of substituted benzothiazoles with 2,4,6-trisubstituted 1,3,5-trioxane by conventional as well as microwave irradiation (solvent free and solid support) methods. All compounds were tested for antiproliferative activity and entomological activity. The microwave irradiation technique gives better yield and reaction completion in a shorter period of time. Among solid supported microwave irradiation better yields are obtained with acidic alumina as compared to silica, neutral alumina and basic alumina.The results of biological activities prompted us that change in substitution pattern in benzothiazolyltriazine derivatives may cause marked effect on their antiproliferative activity.

Synthesized benzothiazole derivatives (IV) and (VI) are screened for their antibacterial activity, antifeedant activity, contact toxicity, stomach toxicity, and acaricidal activity. However, the activities of the tested compounds are significantly lower than those of standard agents. -(CHAUDHARY, M.; PAREEK, D.; PAREEK, P. K.; KANT, R.; OJHA, K. G.; PAREEK*, A.; Bull. Korean Chem. Soc. 32 (2011) 1, 131-136, http://dx.doi.org/10.5012/bkcs.2011.32.1.131 ; Dep. Chem., Gov. Coll. Ajmer, Ajmer 305 001, India; Eng.) -H. Haber