IntroductionCutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45–100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.MethodsA descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Eleven NSCLC patients with EGFR mutation who visited the Hemato-Oncology Clinic/Internal Medicine Department, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, were assessed through history taking, physical examination, and TEWL examination using Tewameter.ResultsTen of the eleven patients experienced cutaneous side effects. The most frequently observed was xerosis cutis (8/10 patients), followed by acneiform eruptions (7/10 patients), and paronychia (3/10 patients). None of these patients experienced hair changes, mucositis, or drug hypersensitivity. Mean TEWL value of these patients was higher than normal (11.205 ± 1.881 g/m2/h).ConclusionsPatients who received gefitinib EGFR inhibitor experienced cutaneous side effects including xerosis cutis, acneiform eruptions, and paronychia, and have mean TEWL values higher than normal. Therefore, it might affect the skin barrier function.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-016-0163-0) contains supplementary material, which is available to authorized users.

Background: Psoriasis is a chronic inflammatory skin disease characterized by alterations in epidermal growth and differentiation. Its primary cause remains unknown, and its clinical and histopathological characteristics sometimes change from time to time. The study aimed to reveal the clinical and histopathological characteristics among psoriasis patients in Dr. Hasan Sadikin General Hospital Bandung. Methods: This study involved 162 medical records of psoriasis patients who visited the Department of Dermato-Venereology and 40 medical records of psoriasis patients who visited the Department of Pathological Anatomy of Dr. Hasan Sadikin Hospital, from 2009 to 2013. Medical record data were collected to describe the patient's clinical and histopathological characteristics of psoriasis. The collected data were analyzed by frequency distribution. Results: From the clinical medical records, the characteristics found among the psoriasis patients were: 14 (8.6%) having familial history, 160 (98.8%) having reddish plaque, 155 (95.7%) having silvery scale, 40 (24.7%) having pustules, 6 (3.7%) having positive Auspitz sign, 48 (29.6%) having nail involvement, and 20 (12.4%) having tongue involvement. In addition, from the histopathological medical records, the characteristics of epidermis among the psoriasis patients found were: 36 (90%) having hyperkeratosis with parakeratosis, 39 (98%) having rete ridge elongation and/or acanthosis, 35 (88%) having Munro's microabcess and/or micropustules of Kogoj, 15 (38%) having thin stratum granulosum, and 30 (75%) having blood vessels dilatation. Conclusions: In psoriasis, the most common clinical characteristics are reddish plaque while the most common histopathological characteristics are elongation of the rete ridges and/or acanthosis.

Objective:To determine the prevalence of gonorrhoea infection in male and female HIV positive patients based on polymerase chain reaction (PCR) examination at the Teratai Clinic, Dr. Hasan Sadikin General Hospital Bandung. . This was a cross-sectional observational study. The subjects were 81 HIV positive patients who were taken in consecutive admission. They underwent history taking and physical examination. Samples were taken from urethral swab in males and cervical swab in females for PCR examination. Results:The PCR examination result was positive for gonorrhea in 36% subjects. From all male subjects participating in the study, 37% were positive while 33% of the female subjects were also positive for gonorrhea. Conclusions:The prevalence of gonorrhoea infection in male and female HIV positive patients at the Teratai Clinic, Dr. Hasan Sadikin General Hospital Bandung is quite high, i.e 37% and 33%, respectively.

Introduction: Herpes simplex virus (HSV) and herpes zoster virus (HZV) are two members of the herpes virus family that can manifest in oral mucosa. Following primary infection, the viruses remain latent and may reactivate if the immune system becomes compromised. The purpose of this study was to know the prevalence and the site of manifestation of HSV and HZV infection in RSUP Hasan Sadikin Bandung from January 2007 until December 2011. Method: The method of this study was descriptive retrospective using secondary data and literature study. Data were taken from medical records of patients in RSUP Hasan Sadikin Bandung, from January 2007 until December 2011. The results were then presented in table and graphs. Result: The study’s result showed the prevalence of HSV infection from 2007-2011 was 6% while the prevalence of HZV infection was 46%. HSV and HZV infection occurred 41% at head and neck, 36% at trunk, 13% at extremities, 7% generalized, and 3% unspecified. The systemic diseases involved in these herpes viruses found in 20.3% patients. Conclusion: The conclusion of this study were the prevalence of HSV infection was low, while the prevalence of HZV infection was high. HSV infection frequently affected at head and neck, and HZV infection frequently affected the trunk. Systemic diseases involved in these herpes viruses were malignancies, neoplasm, internal organ disorders, skin diseases, blood disorder, and nerve disorder.