Objective To report the perioperative outcomes of 200 patients with gynecologic cancer who underwent surgery during the Novel Coronavirus Disease (COVID‐19) pandemic and the safety of surgical approach. Methods Data of patients operated between March 10 and May 20, 2020, were collected retrospectively. Data were statistically analyzed using IBM Statistical Package for the Social Sciences (SPSS) Statistics for Windows v. SP21.0. Results Data of 200 patients were included. Their mean age was 56 years. Of the patients, 54% (n=108), 27.5% (n=55), 12.5% (n=25), and 2% (n=4) were diagnosed as having endometrial, ovarian, cervical, and vulvar cancer, respectively. Of them, 98% underwent non‐emergent surgery. A minimally invasive surgical approach was used in 18%. Stage 1 cancer was found in 68% of patients. Surgeons reported COVID‐related changes in 10% of the cases. The rate of postoperative complications was 12%. Only two patients had cough and suspected pneumonic lesions on thoracic computed tomography postoperatively, but neither was positive for COVID‐19 on polymerase chain reaction testing. Conclusion Based on the present findings, it is thought that gynecologic cancer surgery should continue during the COVID‐19 pandemic while adhering to the measures. Postponement or non‐surgical management should only be considered in patients with documented infection. Gynecologic cancer surgery should continue during the COVID‐19 pandemic while adhering to measures. Only 1% of patients developed COVID‐19‐related symptoms during the postoperative follow‐up period.

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Purpose: Our purpose was to comparatively investigate the expressions of nidogen-1 (NID1) and legumain (LGMN) in patients with endometrial cancer, endometrial intraepithelial neoplasia, and proliferative endometrium. Methods: A cross-sectional, single-center study was performed by the obstetrics and gynecology and pathology departments of our institution. The relationships between descriptive data, clinicopathologic information, and immunohistochemical expressions of NID1 and LGMN were investigated. Results: The histological grades of endometrial cancers (n = 124) as classified by FIGO included 1 (41, 21.1%), 2 (48, 24.7%), and 3 (35, 18.0%). The medians and ranges of deep and superficial NID1 expressions were 50.00 (0-285) and 5.00 (0-100), respectively. The intensity of legumain expression was noted as negative (30, 24.2%), mild (16, 12.9%), moderate (27, 21.8%), or strong (51, 41.1%). Median disease-free survival and overall survival were 75.00 (range: 1 to 170) months and 77.00 (range: 1 to 170) months, respectively. Patients with more intense expression of NID1 and LGMN displayed a higher histological grade. These patients were more likely to have a positive peritoneal cytology, larger tumor size, higher tendency for myometrial or lymphovascular invasion, involvement of ovaries, cervix, omentum, as well as lymph node metastasis, and recurrence. Conclusion: Our data indicated that the expressions of NID1 and LGMN may have important diagnostic implications in endometrial pathologies. Further studies should be performed to understand the significance of NID1 and LGMN in the pathogenesis of endometrial tumors.

he implantation of the fertilized ovum in a region other than the uterine cavity is known as ectopic pregnancy. It is a complication observed in 1%-2% of all pregnancies.1 Despite the progress in diagnostic techniques, ectopic pregnancy remains a crucial cause of maternal morbidity and mortality throughout the world, especially in the countries where prenatal care is poor.2 More than 95% of the ectopic pregnancies are located in the tuba. 3 The etiopathogenesis of tubal ectopic pregnancy has not been clarified yet, though this condition is usually associated with tubal abnormalities and dysfunction, such as abnormal tubal-cilia activity or contractility. 4 Reactive oxygen species produced during metabolic and physiological processes occurring in the body are known as oxidants. Antioxidants play a role in reducing the harmful effects that the oxidants cause in the body. There is a delicate balance between oxidants and antioxidants inside the cells, and if this balance tips in favor of oxidants, a condition of oxidative stress occurs, which may cause cellular damage.5 Any damage that occurs in the tubas at a cellular level may predispose women to a defective tubal transport of the embryo, which is a central process in ectopic preg- , and 30 healthy women who were not pregnant (second control group). All the participants were admitted to the Department of Obstetrics and Gynecology, Gaziantep University Medical School, Turkey. The Erel method was used to measure the total oxidant level (TOL), total antioxidant capacity (TAC), and oxidative stress index (OSI). R Re es su ul lt ts s: : TOL and OSI values were significantly higher in the patient group (p = 0.001) than in the second control group, while there was no significant difference between the patient group and the first control group. The values for TAC were significantly lower in the patient group (p = 0.001) compared to the second control group; however, there was no significant difference between the patient group and the first control group (p = 0.449). C Co on nc cl lu us si io on n: : The role of oxidative stress in the etiopathogenesis of tubal ectopic pregnancy warrants more comprehensive studies in the future.