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ObjectiveTo assess the prevalence of anxiety and depression symptoms, and their associated factors among patients with cancer receiving cancer treatment in Amhara region oncology centres in Northwest, Ethiopia.DesignInstitution-based cross-sectional study was conducted.SettingThree oncology units at comprehensive hospitals in the Amhara region, Ethiopia.ParticipantsAdult patients who had a pathologically confirmed cancer diagnosis and received cancer therapy were our study participants.Main outcome measuresThe Hospital Anxiety and Depression Scale was used to assess anxiety and depression symptoms.ResultA total of 392 patients with cancer participated in this study, of which 57.1% (95% CI 52.1% to 62.1%) and 60.2% (95% CI 55.2% to 65.1%) had anxiety and depression, respectively.Poor social support (adjusted OR, AOR=4.43, 95% CI (1.70 to 11.50)), poor performance status (AOR=1.97, 95% CI (1.02 to 3.79)) and increased pain severity (AOR=1.30, 95% CI (1.14 to 1.48)) were factors associated with anxiety. Furthermore, poor performance status (AOR=2.77, 95% CI: (1.42, 5.39)) and pain severity (AOR=1.25, 95% CI: (1.11 to 1.42)) were significantly associated with depression.Conclusion and recommendationAnxiety and depression were common among patients with cancer. Social support, performance status and pain were determinant factors of anxiety in patients with cancer. Moreover, performance status and pain were associated with depressive symptoms. Therefore, patients with low social support, poor performance status and severe pain should get special emphasis.

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Introduction Fatigue is one of the most commonly and frequently reported symptoms by cancer patients. The cause of fatigue is multifactorial in origin, and its impact varies in range from affecting patients’ daily social life, and physical, mental, economic, and social well-being to becoming a threat to their quality of life. Therefore every cancer patient needs to be screened for fatigue and considered as one of the vital signs. Objective To assess the prevalence of fatigue and associated factors among adult cancer patients, receiving cancer treatment at the oncology unit in Amhara region, Ethiopia, 2022. Method Institutional-based, cross-sectional study was conducted among adult cancer patients receiving cancer treatment from May 9th–June 8th, 2022. A stratified random sampling technique was used to select study participants. Data were entered into Epi data version 4.6 and then exported to the SPSS statistical package version 23 for further analysis. Both bivariable and multivariable logistic regression analyses were carried out. P-values <0.05 in multivariable logistic regression were considered statistically significant. Results The prevalence of cancer-related fatigue was 77.3% at 95% CI (73.1–81.1) with nonresponse rate of 1.97% (9). Poor social support (AOR = 3.62; 95% CI: 1.53–8.60), anxiety (AOR = 3.13; 95% CI: 1.54–6.36), physical inactivity (AOR = 3.67; 95% CI: 1.74–7.54), underweight (AOR = 2.03; 95% CI: 1.05–3.90), anemia (AOR = 2.01; 95% CI: 1.04–3.90), surgery as a treatment modality (AOR = 0.21; 95% CI: 0.06–0.78), combination therapy (AOR = 3.56; 95% CI: 1.68–7.54), treatment less than 3 cycle (AOR = 4.43; 95% CI: 1.53–12.80), and treatment 3–5 cycle (AOR = 3.55; 95% CI: 1.38–9.09) were significantly associated factors with cancer related fatigue. Conclusion Psychosocial assessment and intervention, nutritional support, early intervention of anemia, and promoting exercise are the key elements to minimizing fatigue among cancer patients.

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