In a multicentre study the safety and efficacy of 125 µg intramuscular injection of 15(S)15 methyl PGF , (Prostin 15M, Upjohn) was compared with ergometrine and controls who did not receive any oxytocic for prophylactic control of postpartum bleeding. The study included 441 patients. The duration of third stage was shortened to 6.1 minutes following ergometrine and to 3.5 minutes following Prostin 15M compared to 7.6 minutes in the control subjects. Similarly the blood loss during third stage was less (95.2 ml) in Prostin 15M treated group compared to the untreated control group (233.2 ml). Prostin 15M, when used prophylactically, was also better than ergometrine (154.0 ml) in controlling the blood loss during third stage of labour in normal vaginal delivery.
In a multicentre trial (3 centres) the safety and efficacy of an intramuscular injection of 125 µg of 15(S)15 methyl PGF (Prostin 15M, Upjohn) was compared with methylergometrine for prophylactic control of bleeding during the third stage of labour. Three hundred patients were recruited for the study - 150 to each treatment group. The duration of the third stage was shorter in the patients (4.4 minutes) treated with Prostin 15M compared to the methylergometrine group (8.6 minutes). Similarly the blood loss during the third stage was reduced by 50% of that observed in the methylergometrine group (72 ml vs 145 ml). Prostin 15M, when used prophylactically was better than methylergometrine in controlling the blood loss during the third stage of labour.
A multicentre trial was carried out to find out the safety and efficacy of 15(S)15 methyl PGF (Prostin 15M, Upjohn) for induction of menses in early pregnancy (up to 49 days). Two hundred and eighty-four cases were recruited for the study. All patients received two doses of 0.5 mg (2.0 ml) Prostin 15M by the intramuscular route and antiemetic and antidiarrhoeal medication prior to the administration of the prostaglandin analogue. The overall success rate (complete abortion) at two weeks evaluation visit was 87.7%. The success rate was 92% up to 42 days and 100% up to 35 days of the last menstrual period. The side effects were mainly gastrointestinal and majority of the patients had less than three episodes of vomiting or diarrhoea. The duration of bleeding was prolonged (up to 7 days) with Prostin 15M treatment. Intramuscular Prostin 15M seems to be effective in inducing menses in early pregnancy especially if the duration of amenorrhea is up to 35 days.
The efficacy of 15(S)15 methyl PGF (Prostin 15M, Upjohn) was tested in controlling the bleeding during third stage of labour in women delivered at term. Prostin 15M was given in a dose of 125 µg by intramuscular route at the delivery of the anterior shoulder of the fetus. Prostin 15M significantly reduced the duration of third stage and blood loss to about a third of those who did not receive any oxytocic. The blood loss during 2 hours following delivery was also markedly reduced with Prostin 15M treatment.
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