Multiple ring-enhancing lesions of the brain are one of the most commonly encountered abnormalities on neuroimaging. These can be caused by a variety of infectious, neoplastic, inflammatory or vascular diseases. Distinguishing non-neoplastic causes from neoplastic lesions is extremely important because a misdiagnosis can lead to unwarranted neurosurgery and exposure to toxic chemotherapy or potentially harmful brain irradiation. Diligent clinical evaluation and a battery of tests are required for making a definitive diagnosis. Newer advanced diagnostic techniques, such as diffusion-weighted magnetic resonance imaging (MRI), perfusion-weighted MRI, magnetic resonance spectroscopy, single-photon emission tomography and positron emission tomography may help in establishing the etiology. However, early brain biopsy is often needed because several of these diseases are potentially life-threatening.

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This report describes the serum gonadotropin levels in diabetic men with or without loss of sexual potency and nondiabetic men complaining of impotence; in a small group the gonadotropin response to synthetic LHRH (Hoechst) has also been evaluated.

Freshly isolated rat hepatocytes incubated in a medium containing bovine serum albumin partially purified by charcoal treatment at pH 3 are three times more responsive to insulin with regard to alpha-aminoisobutyric acid uptake than those incubated in medium containing regular bovine serum albumin. This finding should facilitate future work in isolated hepatocytes, a cell system that for the most part has been considered relatively unresponsive to insulin.

303An attempt has been made to understand the possible reasons of failure to oral sulphonylurea therapy in maturity onset diabeties by studying acute changes in blood glucose, plasma FFA, IRI and GH following intravenous (IV) glibenclamide. Material and MethodsAge and sex matched maturity onset diabetics under g1ibenclamide trial were studied in two groups. (I) Controlled: n = 16, diabetics successfully treated with 2.5-20 mg/day of glibenclamide orally. (2) Failure: n"16, those who on uninterrupted therapy for three months with 20 mg glibenclamide daily continued to have hyperglycemia (F & 2 hr pp blood sugar 180 mg/IOO ml).lV g1ibenclamide test was performed after overnight fast and 48 hours after withdrawal of oral drug. A fasting venous blood sam pie was collected, 1 mg glibenclamide was injected IV and subsequently blood was collected after 5, 15, 30,60 and 90 minutes. Blood glucose (Nelson 1944), FFA (Novak 1965), IRI (Welborn and Fraser 1965) and GH (Hartog, Gaafar, Meisser and Fraser 1964) were estimated in each sampie. , LangTimd Vortel (1969), and more recently Greider and McGuigan (1971) demonstrated the presence of gastrin in normal pancreatic islets by mcans of immunofluorescenee. In the same paper, Greider and McGuigan confirmed its presence by radioimmunoassay hut in far smaller levels than in antral gastric mucosa. Applying a biochemical method based on ammonium sulfate precipitation and column chromatographies, we have extracted from hog pancreas a fraction which stimulates gastric acid sccrction in thc rat Although this fraction reacts with porcine gastrin antibodies (Accary. Pointner. Dubrasquet and Bonfi/s 1972) in a radioimmunoassay system, its chromatographie behaviour differs from that of antral gastrin in various systems.. As an explanation of this discrepancy the following hypothesis can be formulated: 1) at least two substances are prcsent, one of them being gastrin; 2) there is only onc sccretagogue substance; in this case immunoreactivity is duc to cross reaction of the fraction with porcinc gastrin antibodics. LomskyDownloaded by: East Carolina University. Copyrighted material.