Serum Gonadotropins (LH and FSH) and their Response to Synthetic LHRH in Diabetic Men with and without Impotence

Gk, Rastogi; Chakraborti, J; Mk, Sinha

doi:10.1055/s-0028-1095718

Cited by 34 publications

(7 citation statements)

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“…We observed an increased response of FSH in impotent when compared with non-impotent diabetics, in contrast to earlier findings [9,11]. This would suggest the possibility of some testicular dysfunction.…”

Section: Discussioncontrasting

confidence: 99%

“…Normal [9] lute•177 hormone (LH) and blunted [10] follicular stimulating hormone (FSH) responses to luteinising hormone releasing hormone (LHRH) stimulation have been reported while blunted LH, but normal FSH, responses were demonstrated by Wright et al [11]. Other aspects of pituitary function have also been studied with the demonstration of raised plasma thyrotrophin (TSH) [12,13] and growth hormone (GH) levels [14,15].…”

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confidence: 99%

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Differences in pituitary and testicular function between diabetic patients on insulin and oral anti-diabetic agents

et al. 1978

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Summary.Pituitary responsiveness to thyrotrophin releasing hormone (TRH) and luteinizing hormone releasing hormone (LHRH) was studied in thirty one male diabetics, of whom sixteen were insulin-dependent and fifteen on oral ant• agents. Ten age-matched controls were also studied. TRH and LHRH were simultaneously administered intravenously, each in a small dose of 10 ~tg followed two hours later by 190 ~tg and 90 ~tg respectively. Basal hormone levels were measured in a further group of thirty six patients (twelve on insulin, twelve on oral agents and twelve on dietary restrictions alone).Higher thyrotrophin (TSH) response was observed following the small dose of TRH in the patients treated with oral agents than in the control subjects. The response of prolactin was lower in patients treated with oral agents compared with those treated with insulin. There was no difference in plasma 73 and T 4 levels in the patients treated with insulin or oral agents. Significantly higher basal growth hormone (GH) levels were observed in the diabetics. The insulin-dependent group showed a more marked response of GH to TRH/LHRH. No response was observed in the controls. Plasma testosterone levels were significantly lower in the oral agent group (13.8 nmol/1) than in the insulin group (19.4 nmol/1), patients on dietary restrictions (18.4 nmol/1) and the control subjects (19.0 nmol/1). The LH response to the smaller dose of LHRH was impaired in patients on insulin and oral agents. There was a significant difference in FSH response between impotent and sexually normal patients.

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Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

Differences in pituitary and testicular function between diabetic patients on insulin and oral anti-diabetic agents

et al. 1978

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“…There were no significant differences in the serum concentrations of FSH and LH in the fertile normozoospermic men and the diabetic patients. Such results are in agreement with those of other authors [7,9,11,19,20,28,32,35,411 and suggest a normal functioning of the hypothalamic-pituitary leydig cell axis in subjects with type I diabetes mellitus. Our results coincide with those of other authors in the observation that serum testosterone levels in diabetic men are similar [19,281 or lower [2, 10, 151 than those shown by normal subjects.…”

Section: Discussionsupporting

confidence: 93%

“…The serum and urinary gonadotropins may be normal [7,9,11,19,20,28,32,35,391 or low [34] or have high-follicle-stimulating-hormone (FSH) levels [16,20,24,281 or high-LH levels [2,6,7,161. The response of FSH to stimulation with exogenous gonadatropin-releasing hormone (GnRH) in diabetic subjects may be normal [7,9,11,14,32, 391, below normal [41], or exaggerated [20,241. A normal response of LH to stimulation with exogenous GnRH has been reported [14, 321, as has a decreased response [2, 9, 35, 39, 411. Plasma testosterone concentrations are similar to [2,14,19,20,24,28,31,39, 401 or lower than [15, 31 those in normal men.…”

Section: Introductionmentioning

confidence: 99%

Semen Characteristics and Diabetes Mellitus: Significance of Insulin in Male Infertility

García-Díez¹,

Corrales²,

Hernandez-Diaz³

et al. 1991

Archives of Andrology

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A study was made of semen quality and serum hormonal profiles (FSH, LH, prolactin, testosterone) of patients with type I diabetes mellitus. Semen parameters and levels of prolactin and testosterone were significantly altered in the diabetic state. The concentration of insulin in serum and seminal plasma and the serum levels of FSH, LH, and testosterone were measured in 80 men classified in the following groups: fertile subjects, infertile normoglycemic subjects, subjects with carbohydrate intolerance, and excretory and secretory azoospermic subjects. In all groups, seminal insulin concentrations were higher than those obtained in serum. The hormone appears to freely cross the blood-testis barrier, there to be concentrated in the semen. The levels of insulin in serum and seminal plasma did not correlate with semen parameters and are not suitable markers of seminal quality. For unknown reasons, the concentrations of insulin in seminal plasma were lower in the subjects suffering from carbohydrate intolerance.

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“…413 The LH response to LHRH also suggests that testicular function is normal, the characteristic finding in primary gonadal failure in men being an exaggerated serum LH response. 14 The normal gonadotrophin response to LHRH in diabetic men with and without impotence has been reported by Rastogi et al 15 Our findings of a lowered LH increment remain unexplained, as the LH increment did not correlate with any other clinical or biochemical findings. The lowered LH increment was not due to delayed response, as the maximum serum concentration was seen at 30 minutes in both normal subjects and diabetic patients.…”

Section: Discussionsupporting

confidence: 53%

Luteinizing Release Hormone Tests in Impotent Diabetic Males

et al. 1976

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Assessment of pituitary-gonadal function was made in impotent diabetic males using luteinizing hormone-release hormone tests. Serum testosterone, sex-hormone-binding globulin capacity, and basal and incremental gonadotrophin concentrations in the impotent diabetics were similar to those in control diabetics, suggesting a primary neurologic rather than an endocrine defect as the cause of the impotence.

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Serum Gonadotropins (LH and FSH) and their Response to Synthetic LHRH in Diabetic Men with and without Impotence

Abstract: This report describes the serum gonadotropin levels in diabetic men with or without loss of sexual potency and nondiabetic men complaining of impotence; in a small group the gonadotropin response to synthetic LHRH (Hoechst) has also been evaluated.

Cited by 34 publications

References 0 publications

Differences in pituitary and testicular function between diabetic patients on insulin and oral anti-diabetic agents

Differences in pituitary and testicular function between diabetic patients on insulin and oral anti-diabetic agents

Semen Characteristics and Diabetes Mellitus: Significance of Insulin in Male Infertility

Luteinizing Release Hormone Tests in Impotent Diabetic Males

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