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This report describes the serum gonadotropin levels in diabetic men with or without loss of sexual potency and nondiabetic men complaining of impotence; in a small group the gonadotropin response to synthetic LHRH (Hoechst) has also been evaluated.

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Contemporary endocrinology has doubtlessly established the existence of a negative feedback loop system between the Leydig and the pituitary cells. However, the physiology of this endocrine circuit cannot adequately explain the blood testosterone fall observed during a surgical stress (CluJrters, Odelt and Thompson 1968); it was indeed reported that neither blood ICSH, FSH and TSH levels did vary significantly during such stressful situations.Recently, we reported a significant (p < .005) blood testosterone increase in 23 healthy varsity students undergoing a 30-Requests for reprints should be addressed to: Or.Oisturbances of gonadal function are common in adrenal disorders. Intake of large amounts of glucocorticoids or Cushing's syndrome are associated with menstrual disorders. Amenorrhea and irnpaired fertility are sequelae of untreated adrcnogenital syndrome. Glucocorticoid administration depressed and metyrapone enhanced LH response to LHRH in men and women (Sakakura, Takebe and Nakagawa 1975). We re port here the LH and FSH responses to GnRH in heaIthy men hcforc and after metyrapone.

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