The objective of this study was to control the elevated blood pressure in the patient with sudden episode of high blood pressure having markedly reduced function ability and restlessness. In such a case rapid onset of action is required. Prazosin Hydrochloride is drug with short biological half life. The purpose of study is to mask the bitter taste of drug and provide rapid onset of action. Inclusion complex of drug and β-Cyclodextrin can prepare by kneading method to mask the bitter taste of drug. 3 2 full factorial design was implemented, direct compression method were used to prepare tablet. F2 batch among all other batches showed disintegration time 55 sec with 98.56%drug release within 5min. thus it can be concluded the fast dissolving tablet can be formulated for antihypertensive drug.

Two simple, rapid and economic UV spectrophotometric methods, namely successive ratio derivative and double divisor ratio spectra methods, have been developed for the simultaneous estimation of ternary mixtures of erdosteine, guaiphenesin and terbutaline sulphate without preceding separation steps. Method I is based on successive derivative of ratio spectra in two steps, whereas method II is based on convolution of double divisor ratio spectra, obtained by dividing the absorption spectrum of the ternary mixture by a standard spectrum of two of the three compounds in the mixture. All the drugs exhibited good linearity over the reported concentration range with acceptable correlation coefficient. The methods were validated according to ICH guidelines for the evaluation of accuracy, precision, sensitivity. The obtained relative standard deviation i.e. less than 2%, demonstrated that the proposed methods were accurate and precise and can be employed for routine analysis in quality control laboratories, eliminating the need of prior separation of the pharmaceutical mixtures.

The present study was aimed to develop and validate a simple, rapid, accurate, precise, and sensitive HPTLC method using DoE approach for the simultaneous estimation of erdosteine, guaiphenesin and terbutaline sulphate in syrup formulations. HPTLC separation was performed on aluminium plates precoated with silica gel 60 F254 as the stationary phase, three different factors like methanol content, chamber saturation time and distance travelled were optimized using Box-Behnken Design Good separation was obtained with toluene:dichloromethane:methanol:glacial acetic acid (4:4:1.81:0.2; % V/V/ V/V) mobile phase. Quantification was achieved by densitometric analysis of erdosteine, guaiphenesin and terbutaline sulphate over the concentration range of 500-3000, 200-1200 and 25-150 ng/band, respectively, at 225 nm. The method was validated for precision, accuracy, robustness, specificity, limit of detection and limit of quantitation as per ICH guideline. The method was successfully applied for the quantitative determination of erdosteine, guaiphenesin and terbutaline sulphate in in-house dosage form, i.e. syrup.