Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in theOcular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in sitespecific drug delivery.

Objective:A simple, precise, accurate method was developed for the simultaneous estimation of azilsartan and chlorthalidone in bulk and tablet dosage form by RP-HPLC technique.Methods: Acetonitrile and water in the ratio of (70:30) pH 2.8 used as mobile phase run through (Cosmosil C18 (4.6ID x 250 mm, Particle size: 5 micron) column with a flow rate of 0.9 ml/min. The temperature of the column oven was maintained at 30 °C. Wavelength was selected 244 nm. Stock and working solutions were prepared by using the diluents water and acetonitrile in the ratio of 50:50. Runtime was fixed to 9 min.Results: Chlorthalidone and azilsartan were eluted at 2.02 and 3.92 with good resolution the plate count, tailing factor and all system suitability parameters are within ICH range. Azilsartan Medoxomil and Chlorthalidone were found to be linear low in concentration range of 80-400μg/ ml and 25-125μg/ ml respectively in the linearity study, regression equation and coefficient of correlation for Azilsartan Medoxomil and Chlorthalidone were found to be (y = 28695x+15397 r²=0.995) and (y=13444+27405 r² = 0.996) Percentage recovery for both Azilsartan Medoxomil and Chlorthalidone was found in range of 99.89%-99.96% indicating accuracy of the proposed work. Assay of the tablet was performed and found as 100.15%. Conclusion:All the parameters were within the ICH guidelines, and the method was economical and simple as retention times were less than in literature and decreased run time.

Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments, creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) and dermal drug delivery system can provide some desirable performances over conventional pharmaceutical dosage formulations, such as avoiding gut and hepatic first-pass metabolism, improving drug bioavailability, reducing dose frequency and stabilizing drug delivery profiles. The aim of this review was to search for alternatives to the conventional forms in order to reduce skin irritation, improve skin adhesion properties, enhance the drug release and increase the patient acceptability from an aesthetic perspective. Because of their peculiar rheological behaviour, polymeric gels are beneficial in terms of ease of preparation, ease of application, adhesion to the application surface and ability to deliver a wide variety of drugs.

Simple and accurate UV spectrophotometric methods by Zero, First and Second order derivative method  have been developed and validated for the estimation of Olopatadine hydrochloride in bulk and its pharmaceutical dosage form. The standard and sample solutions of Olopatadine hydrochloride were prepared in methanol and water. Olopatadine hydrochloride was estimated at 299, 289 and 267 nm for the  derivative UV-spectrophotometric method. Beer’s law was obeyed in the concentration range of 20 to 120 μg / mL with coefficient of correlation value 0.9996, 0.999 and 0.999 for Zero, First and Second order derivative method. These methods were tested and validated for various parameters according to ICH and USP guidelines. The precision expressed as relative standard deviation were of less than 2 for the above three methods respectively. The proposed methods were successfully applied for the determination of Olopatadine hydrochloride in pharmaceutical dosage form. Results of the analysis were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply, low-cost and require relatively inexpensive instruments. Keywords: Olopatadine HCl, UV-Visible spectrophotometry, Pharmaceutical Dosage forms, Derivative Spectroscopy, Method validation.

The objective of this study was to control the elevated blood pressure in the patient with sudden episode of high blood pressure having markedly reduced function ability and restlessness. In such a case rapid onset of action is required. Prazosin Hydrochloride is drug with short biological half life. The purpose of study is to mask the bitter taste of drug and provide rapid onset of action. Inclusion complex of drug and β-Cyclodextrin can prepare by kneading method to mask the bitter taste of drug. 3 2 full factorial design was implemented, direct compression method were used to prepare tablet. F2 batch among all other batches showed disintegration time 55 sec with 98.56%drug release within 5min. thus it can be concluded the fast dissolving tablet can be formulated for antihypertensive drug.