The water-adsorptive capabilities of Gd2O3@MCM-41 as contrast agents with various gadolinium additions were evaluated by molecular dynamic simulation, which indicates that increasing gadolinum leads to the decrease in water molecules adsorbed on the surfaces of mesoporous silica and Gd2O3 nanocluster. Gd2O3@MCM-41 nanoparticles were synthesized by a one-step method. The measured microstructure and water-adsorptive capability of Gd2O3@MCM-41 consist with their simulated counterparts. The observation disclosed that the nanoparticles injected within mice were distributed in their liver and tumor. The enhancement of in vivo magnetic resonance imaging was detected in the tumor and inferior vena cava of the mice contrasted with Gd2O3@MCM-41.
Gd2O3@SiO2 nanoparticles with a core-shell structure are synthesized by pulsed laser ablation in liquid (PLAL) in single steps. A Gd2O3 target immersed in tetraethyl orthosilicate (TEOS) is ablated by a microsecond Nd:YAG laser, which induces the generation of a Gd2O3 plasma plume and pyrolysis of the TEOS. We propose that the moment Gd2O3 nanoparticles are formed they will be coated immediately by SiO2 and directly synthesized Gd2O3@SiO2 core-shell nanoparticles. These particles obtain high 𝑟1 relaxivity of 5.26 s −1 mM −1 and are used as 𝑇1-weighted magnetic resonance imaging contrast agents. It is shown that the PLAL technique is promising for fabricating core-shell structure nanomaterial with potential medical applications.
We first synthesized gadolinium oxide (Gd2O3) by a modified “polyol” strategy and then embedded it into mesoporous silica by a simple self-assembly sol-gel reaction. Scanning electron microscope (SEM) results show that the samples have good sphericity and good dispersibility. The structure of mesoporous silica was characterized by transmission electron microscopy (TEM) and small-angle X-ray diffraction (SAXRD). Results show that the mesoporous structure has not been destroyed after gadolinium oxide imbedding. The ratio of gadolinium and silica was determined by the mean of energy dispersive spectroscopy (EDS).
In this work, titanium oxide nanorod arrays were fabricated by using the hydrothermal method on fluorine-doped tin oxide (FTO) coated glass. The diameter of the nanorods could be controlled from 150 nm to 30 nm by changing the growth parameters. The surface morphology and the structure of the samples were characterized by SEM and XRD. The wetting properties were identified by contact angle measurement. Platelet attachment was investigated to evaluate the blood compatibility of the samples with different nanoscale topographies. Results show that the nanotopographical surfaces perform outstanding blood compatibility, and the adhering platelet decreased with the increasing diameter of the nanorods.
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