Background Nowadays, the age of patients qualified for lung surgery has been lowered. These people have increasingly higher requirements for postoperative quality of life, which is closely related to pulmonary function (PF). Therefore, it’s meaningful to analyze the effects of different surgical methods on postoperative PF and postoperative recovery. Methods A total of 171 patients underwent thoracoscopic lung surgery were selected in our study: unilateral lobectomy (UL), unilateral sublobectomy (USL), and other surgical method (OSM). Other operations included unilateral/bilateral lobectomy and/or sublobectomy. Study indicators included patient general condition, PF and recovery condition. Results The USL was in the best condition during and after surgery. Then was OSM, USL was the worst. All the thoracoscopic operations significantly reduced PF and the loss of PF in the UL was significantly higher than USL. In the long-term observation, the loss of PF after lobectomy was almost the same. The compensatory capacity of the upper lobe was better than the lower lobe. The prediction models of PF cannot fully reflect the actual situation after operation. Our PF loss assessment table based on clinical data was constructed to correct existing models. Conclusions Surgeries had significant effects on PF, but these changes gradually disappeared after operation. The greatest affect were PEF and PEF%, the least were MVV and MVV%. The compensatory function of the upper lobe was better than lower one. The loss of PF in multiple lung tissue resection is equivalent to lobectomy. Our postoperative PF assessment table can better reflect the PF than existing prediction models.

Integrins are closely related to the occurrence and development of tumors. ITGA8 encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein; very little literature on the mechanism of this gene in the occurrence and development of lung cancer is available. Through the public database, we found that the expression of ITGA8 in tumor tissue was significantly lower than that in normal tissue, especially in lung cancer, renal carcinoma, and prostate cancer. In lung adenocarcinoma, survival analysis revealed that patients with higher ITGA8 expression had a better prognosis. ITGA8 was positively related to immune checkpoints genes and immunomodulators genes, whereas B cell, CD4 + T cell, CD8 + T cell, neutrophil, macrophage, and dendritic cell infiltration had the same correlation. Moreover, ITGA8 was negatively related to cancer stemness. Through the online database, we predicted the miRNAs and lncRNAs that regulated ITGA8 and obtained the regulatory network of ITGA8 through the correlation analysis and the Kaplan–Meier survival analysis. Using quantitative real-time polymerase chain reaction and Western blot analyses, it was verified that LINC01798 regulated the expression of ITGA8 through miR-17-5p. Therefore, the regulatory network of ITGA8 may serve as a new therapeutic target to improve the prognosis of patients with lung cancer.

Synovial sarcoma is a highly malignant tumor that accounts for 10% of all soft tissue sarcomas. Primary pulmonary synovial sarcoma (PPSS) is extremely rare, and its prognosis is poor. A diagnosis is usually established after other primary lung malignancies or metastatic extrathoracic sarcomas have been excluded. Therefore, it is often misdiagnosed. In this study, we report the case of a 38-year-old woman who was misdiagnosed as having pleural mesothelioma and finally endured surgery to remove the tumor. The tumor showed SYT-SSX fusion transcripts and was diagnosed as PPSS after combining histopathological and immunohistochemical analyses. Finally, we determined some biomarkers through whole-exome sequencing (WES) to improve the diagnosis and treatment strategies.