While leprosy is not considered a public health problem in Colombia, affected children are an important warning sign, demonstrating the challenge of controlling the disease. Herein, we report 12 cases of leprosy in patients 5-17 years of age, summarizing our clinical, micro biological and treatment findings.

Background Worldwide SARS-CoV-2 infections increase every day. Despite the infection is less severe in children, it can be severe and associated with complications. However, local data remain scarce. We sought to describe epidemiological and clinical characteristics of COVID-19 infection in this population across different age groups. Methods Observational, multicenter study across 23 Colombian hospitals from 22 different territories. We included all patients from 0 months to 17 years with confirmed SARS-CoV-2 infection by either antigen or RT-PCR testing. Results From March 1, 2020, to October 31, 2021, we identified 1,186 patients: neonates (88), 1 to 3 months (130), 4 to 23 months (306), 2 to 4 years (169), 5 to 11 years (229) and 12 to 18 years (226) with confirmed COVID-19 infection. Of those,77(6.2%) were asymptomatic, 631(53.2%) hospitalized, 132(11.2%) required PICU. 58 cases met WHO definition of MIS-C. Patients less than 24 months of age were characterized by fever (74%) and more respiratory distress (30.1%) compared to other groups. Patients >5yo seemed to have a more severe presentation. They had more gastrointestinal (GI) symptoms (31% vs 37.8%), had more need for ICU care given presentation with shock increased with age ( >5yo 9.5%; 5-12yo 10.6%; 12-18yo 11.5%). Lab markers including thrombocytopenia and Lymphopenia were more common on this age group. Antibiotic treatment was common (%%) especially in neonates (40.9%), despite bacterial coinfection was rare (8.7%), length of hospitalization was longer in older than 2-year-old groups. 23(1.9%) patients died, similar across different age groups. Heat map by age group Conclusion COVID-19 infection in Colombian children presented differently across different age groups. Children older than 5 years had a more severe clinical course and prolonged hospital stays. Clinical findings according to age groups could help clinicians in characterizing and identifying COVID 19 infections in Children. Disclosures Ivan Felipe Gutiérrez Tobar, n/a, Pfizer and MSD (Advisor or Review Panel member, Research Grant or Support, Speaker’s Bureau, Has received support from Pfizer and MSD for participation in congresses and has received conference payments from Pfizer)Pfizer and MSD (Speaker’s Bureau, Other Financial or Material Support, Has received support from Pfizer for participation in congresses) Juan P. Rojas -Hernandez, Candidate for doctorate in Public Health, Pfizer (Other Financial or Material Support, Has received support from Pfizer for participation in congresses) Eduardo López Medina, n/a, Pfizer (Other Financial or Material Support, Has received support from Pfizer for participation in congresses)

Introducción: Clostridioides difficile (C. difficile) es la causa más común de diarrea asociada a la atención en salud en adultos. En Medellín, son frecuentes las infecciones asociadas al cuidado de la salud por este microorganismo en hospitales de alta complejidad.Objetivos: Identificar los factores clínicos y epidemiológicos asociados a la infección por C. difficile en un hospital universitario de alto nivel de complejidad de la ciudad de Medellín - Colombia.Métodos: Estudio epidemiológico transversal retrospectivo para determinar la prevalencia y evaluar posibles factores asociados a infección por Clostridioides difficile. Se incluyeron 156 pacientes internados en un hospital de alta complejidad de Medellín entre los años 2016 - 2018 que presentaron deposiciones líquidas con criterios clínicos de infección y a quienes se solicitó estudio de toxina para C. difficile (Immunocard®) con resultado positivo. Resultados: Se encontró una prevalencia general del 50 % y una mortalidad atribuible a infección por C. difficile de 11,5 %. El análisis de razones de prevalencia (RPa) mostró que los factores que incrementaron las posibilidades de la infección fue procedencia de zona urbana (RPa= 3,39; IC95 % 1,03 - 11,15), recibir antibióticos durante más de 22 días (RPa= 1,81; IC95 % = 1,11 - 2,95), antecedente de diabetes (RPa = 1,65; IC95 % = 1,16 - 2,35), neoplasia sólida (RPa = 1,64; IC95 % = 1,11 - 2,41) y hospitalización previa en la institución (RPa = 1,58; IC95 % = 1,13 - 2,21).Conclusión: En este trabajo se evidenciaron asociaciones con infección por C. difficile de factores similares a lo descrito en la literatura como las comorbilidades, exposición a antibióticos y la atención hospitalaria.