ObjectiveTo compare the outcomes of embryo development between oval-shaped oocyte as an abnormal morphology oocyte and a normal morphology oocyte in In Vitro Fertilization (IVF).MethodsThis study was a comparative analytical study with retrospective approach which lasted from September 2014 until November 2015. For this study, we used secondary data (medical records) from 24 patients submitted to IVF at the Halim Fertility Center. The oocyte morphology was divided into two groups: normal-shaped oocyte and oval-shaped oocyte.ResultsOur study included 120 oocytes with 60 oval-shaped oocytes and 60 normal oocytes. We found fertilization rates of 68.3% in the normal oocyte group and 61.7% in the oval-shaped oocyte group; and there was no significant difference between the normal oocyte group and the oval-shaped oocyte group (p > 0.05). In the normal oocyte group, 65% had reached day 3 embryos, and in the oval-shaped oocyte group it was 50%, with no significant difference between the groups (p > 0.05). We also found 46.7% transferrable embryos in the oval oocytes group compared to 63.3% in the normal oocytes group, with no significant difference between the groups (p > 0.05).ConclusionThere was no significant difference in fertilization rates and embryo quality between normal morphology oocytes and oval-shaped oocytes.

<p><strong>Introduction</strong></p><p>HIV serodiscordant couple who wish to have offspring but fear of disease contagious prohibittedthem from concieved naturally. Intrauterine insemination without having direct sexual contact is one of the method to achieve this wish. This study was aimed to evaluate the outcome of intrauterine insemination in HIV serodiscordant couple.</p><p><strong>Material and methods</strong></p><p>Retrospective analytic study was done. HIV serodiscordant couple who have been treated with intrauterine insemination from January 2010 until June 2014 in Halim Fertility Centre Medan was included in this study.</p><p><strong>Results</strong></p><p>There were 27 cycles of intrauterine insemination from HIV serodiscordant couple. The clinical pregnancy rate were 33.3%. None of the babies or mother after deliveries have HIV positive.</p><p><strong>Conclusion</strong></p><p>Intrauterine insemination in HIV serodiscordant couple appears to be effective and safe method to achieve pregnancy. </p>

Background: Studies have been conducted to improve the pregnancy rate through the in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) program. In recent years, researchers have been focusing on finding impact of high progesterone level on endometrial receptivity. However, data on whether progesterone level also affects the quality of the embryo is still limited. Objective: The aim is to assess the effect of late follicular progesterone level on the outcome of in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI). Materials and Methods: This was a case-control of 245 women who underwent in vitro fertilization cycle at Halim Fertility Center, Indonesia. The outcomes assessed were number of oocytes retrieved (OR), maturation rate (MR), fertilization rate (FR), number of good embryos (GE), number of fair embryos (FE), and number of poor embryos (PE). The progesterone (P4) and estradiol (E2) levels were analyzed on the day of human chorionic gonadotropin injection. Serum progesterone level was divided into three groups: 1. low progesterone (≤ 0.50 ng/ml), 2. normal progesterone (0.51-1.50 ng/ml), and 3. high progesterone (> 1.50 ng/ml). All outcomes were compared amongst the groups. Results: Significant differences occurred between progesterone level on the day of human chorionic gonadotropin administration. The number of OR in group 1, 2, and 3 were 8.41 ± 5.88 vs. 12.99 ± 8.51 vs. 17.58 ± 9.52, respectively. Conclusion: Progesterone level on the day of human chorionic gonadotropin injection may have an impact on the outcome of IVF-ICSI. Key words: Intracytoplasmic sperm injection, Embryo, Progesterone, In vitro fertilization.