Introduction. Breast cancer is the most frequently diagnosed malignancy in women, and comorbidities like hypertension and obesity diminish their quality of life and negatively affect their response to chemotherapy. Furthermore, inulin supplementation is associated with the reduction of cardiovascular diseases (CVD) risk. Objective. To determine whether inulin supplementation prevents the elevation of blood pressure in women with breast cancer undergoing neoadjuvant therapy with cyclophosphamide and doxorubicin. Methods. This was a randomized, double-blind placebo controlled trial which included women with early-stage breast cancer undergoing neoadjuvant therapy (n=38). Patients were randomly assigned to participate in two different groups to receive either 15 g of inulin or 15 g of placebo (maltodextrin) for 21 days. Body composition and blood pressure were evaluated before and after the supplementation period. Results. Women in the inulin group showed a lower systolic blood pressure (SBP) after the supplementation (-4.21 mmHg, p<0.001). However, SBP increased in the placebo supplemented group. Diastolic blood pressure (DBP) nonsignificantly decreased in the inulin group. Inulin supplementation also increased BMI (p<0.001) but reduced BFP (p=0.288). Furthermore, confounding variables, such as BMI, baseline fasting glucose, age, menopause status, vomiting, constipation, and chronic medication did not have a statistical influence over the inulin effect on SBP. Conclusion. Inulin supplementation reduces SBP and prevents increases in DBP in women with breast cancer. This could be an innovative nutraceutical approach to prevent hypertension present in women with this type of cancer at an early stage and may improve the quality of life of the patients and their prognostic development through chemotherapy. Trial Registration Number. This trial is registered with ACTRN12616001532493.

Radiotherapy is a fundamental part of the treatment of pelvic neoplasms. Up to 90% of patients develop gastrointestinal symptoms as a result of acute injury to the small and large intestine, particularly in the mucosa. Radiotherapy leads to atrophy of the intestinal epithelium, acute crypt inflammation, inflammatory infiltration of the epithelium, malabsorption of lactose, and biliary salts as well as alterations in pancreatic enzymes and biliary salts, resulting in the malabsorption syndrome and dysbiosis. The most commonly reported symptoms of pelvic radiation disease include changes in bowel habits (94%), decreased fecal consistency (80%), frequency of bowel movements (74%), bowel urgency (39%), and fecal incontinence (37%). Although nutritional interventions with dietary modifications have been reported to prevent and treat gastrointestinal symptoms, the evidence remains inconclusive.

Introduction: Cervical cancer (CC) is a public health problem; it is the second most common cause of cancer in Mexico and the third cause of death worldwide. Malnutrition in the cancer patient is present in 80-90% of cases of advanced disease. Objective: To analyze the relationship of the nutritional status of patients with clinical Stage IV and recurrent CC with palliative chemotherapy-associated toxicity. Materials and methods: This was a prospective, descriptive, and observational study. Patients with clinical Stage IV CC recurring on palliative chemotherapy were recruited. Nutritional status was assessed before treatment as well as its relationship with toxicity. Associations between qualitative categorical variables were searched for with Spearman's correlation, and statistically significant differences (p < 0.05) for dichotomous variables were looked for using Fischer's exact test. Results: A total of 17 patients were included, out of which 5 (29.4%) had normal nutritional status, 8 patients (47%) had moderate malnutrition, and 4 patients (23.5%) had severe malnutrition. A positive correlation was found between the degree of malnutrition and the presence of diarrhea (rho = 0.626), nausea (rho = 0.556), and hypoalbuminemia (rho = 0.559). Conclusions: Nutritional status before chemotherapy was shown to be highly important, since a malnutrition status implies higher toxicity by the treatment, which entails an increase in malnutrition for the next chemotherapy session as well as hospital readmissions. (creativecommons.org/licenses/by-nc-nd/4.0/).

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Estado nutricional en pacientes con cáncer cervicouterino tratados con QT/RT concomitante: el efecto de la terapia nutricional en una experiencia de 5 años Emigdio Jaimes-Alpízar Resumen Introducción: El cáncer cervicouterino (CaCu) representa la segunda causa de muerte en la mujer en México, la quimioradioterapia (QT/RT) concomitante presenta diversos cuadros clínicos que afectan el estado nutricional en estos pacientes. Método: Estudio observacional, retrospectivo, descriptivo y longitudinal, en el cual se revisaron expedientes de cinco años y se evaluó el estado nutricional en pacientes con CaCu valorando: peso e índice de masa corporal (IMC), albúmina, hemoglobina, linfocitos y proteínas totales, al inicio y al final del tratamiento. Los datos se analizaron mediante el programa SPSS utilizando la prueba t de Student para variables cuantitativas, se tomó como significancia estadística p ≤ 0.05. Resultados: Se incluyeron un total de 200 pacientes, 170 fueron derechohabientes del Seguro Popular (SP) y 30 pacientes derechohabientes del Instituto de Salud del Estado de México y Municipios (ISSEMyM). S e observó que en ambos grupos existe una disminución del peso significativa, la diferencia absoluta en el grupo ISSEMyM fue de 3.0934 kg, mientras en el grupo SP fue de 3.6583 kg. Discusión: Las pacientes de Seguro Popular presentaron una pérdida de peso grave (> 5%) en un mes (p ≤ 0.05), no siendo así en las pacientes del ISSEMyM, en las cuales la pérdida de peso fue menor al 5% en un mes. Las diferencias entre los valores de hemoglobina, linfocitos, albúmina y proteínas totales para ambos grupos no fueron estadísticamente diferentes. Conclusiones: La terapia nutricional en este grupo de pacientes debe ser obligatoria. Tal y como se demostró en este estudio, la pérdida de peso es menor en las pacientes que la reciben.(creativecommons.org/licenses/by-nc-nd/4.0/). Abstract Introduction: Cervical cancer represents the second cause of death in women in Mexico. Concomitant chemoradiotherapy presents several clinical conditions that affect the nutritional status of these patients. Methods: Retrospective, descriptive, longitudinal, and observational study, in which 5-years histories were reviewed, and nutritional status was eva- PALABRAS CLAVECáncer cervicouterino; Quimioterapia; Radioterapia; Terapia nutricional KEY WORDSCervical cancer;