The effects of green tea (GT) in obese subjects have been evaluated in different studies, but no consensus has been obtained due to the heterogeneity of the results. The dosage, the type of extract, and the duration of the intervention are the main contributors to the heterogeneity of the results. Therefore, the present systematic review and meta-analysis aimed to evaluate the efficacy and dose-response relationship of GT. Several databases were searched from inception to September 2019 to identify clinical trials that examined the influence of GT supplements on obesity indices in humans. Combined results using the random-effects model indicated that body weight (WMD: −1.78 kg, 95% CI: −2.80, −0.75, p = .001) and body mass index (BMI) (WMD: −0.65 kg/m 2 , 95% CI: −1.04, −0.25, p = .001) did change significantly following GT administration. The reduction in waist circumference (WC) after GT consumption was significant in subjects in trials employing GT ≥800 mg/day (WMD: −2.06 cm) and with a treatment duration <12 weeks (WMD: −2.39 cm). Following the dose-response evaluation, GT intake did alter body weight, with a more important reduction when the GT dosage was <500 mg/day and the treatment duration was of 12 weeks. The results of present meta-analysis study support the use of GT for the improvement of obesity indices. Thus, we suggest that the use of GT can be combined with a balanced and healthy diet and regular physical exercise in the management of obese patients. K E Y W O R D S body mass index, dose-response, green tea, meta-analysis, obesity, weight 1 | INTRODUCTION Obesity is an important public health problem and a major contributor to the health burden globally (OECD, 2019). The presence of obesity significantly increases one's risk of non-communicable diseases, for example, diabetes mellitus, cardiovascular disease and cancer (Gaman, Epingeac, & Gaman, 2019; Goossens, 2017). According to the World Health Organization (WHO), obesity is characterized by an abnormal or excessive fat accumulation and is diagnosed clinically based on values of the body mass index (BMI) (kg/m 2) > 30 kg/m 2 (WHO, 2018). Since 1975, the prevalence of obesity has nearly tripled, with almost one-third of the world population being obese (Forse & Kissee, 2020). In 2016, 39% of the adults aged >18 years were reportedly overweight and 13% were obese (WHO, 2018). Obesity is a multifactorial chronic disease whose development results from an imbalance between the energy intake and expenditure

Hydrocephalus is widely known as “hydrocephaly” or “water in the brain,” a building up of abnormal cerebrospinal fluid in the brain ventricles. Due to this abnormality, the size of the head becomes larger and increases the pressure in the skull. This pressure compresses the brain and causes damage to the brain. Identification by imaging techniques on the hydrocephalus is mandatory to treat the disease. Various methods and equipment have been used to image the hydrocephalus. Among them, computerized tomography (CT) scan and nuclear magnetic resonance (NMR) are the most considered methods and gives accurate result of imaging. Apart from imaging, cerebrospinal fluid-based biomarkers are also used to identify the condition of hydrocephalus. This review is discussed on “hydrocephalus” and its imaging captured by CT scan and NMR to support the biomarker analysis.