Alchornea cordifolia (Euphorbiaceae) is widely used in Africa for the treatment of malaria, fever, tooth decay, leprosy, amoebic dysentery, hemorrhoids, headaches, venereal diseases and inflammation. It is also used as emmenagogue and oxytocic. Quassia africana (Simaroubaceae) is also widely used in Africa for the treatment of malaria, gastritis, intestinal worms, rheumatism, bronchopneumonia, gonorrhea, headache, tooth decay and tonsillitis. The present study aims to highlight the analgesic and antipyretic effects of both plants. Fever was induced by oral administration of 20 ml / kg of 20% beer yeast in rats 24 hours before treatment. The rectal temperature was measured 1h, 2h and 3h after treatment. The pain was induced by intraperitoneal injection of 0.1 ml / 10 g of 0.6% acetic acid in rats 1 hour after oral treatment. The analgesic activity was assessed for 10 minutes by counting the number of cramps. The aqueous, ethanolic and dichloromethane extracts of the leaves and fruits of Alchornea cordifolia at 400 and 800 mg / kg per os showed a very significant antipyretic effect identical to paracetamol at 100 mg / kg per os. The aqueous extracts of the leaves and fruits of Alchornea cordifolia as well as barks of Quassia africana at 400 and 800 mg / kg per os showed a very significant analgesic effect. These effects are related to the presence of alkaloids and terpenes for Alchornea cordifolia and Quassinoides for Quassia africana.

The purpose of this work is to evaluate antiprolifertive and DPPH radical scavenging activities of aqueous extracts from Morinda lucida Smith, Klainedoxa gabonensis Pierre ex Engl, Tephrosia vogelii Hook f and Nauclea latifolia Sm. The antiproliferative activity of the aqueous extract of each of the four species was evaluated in vitro on a cancer cell line (U87-MG) and a normal cell line (Hek-293) using the MTT assay. The antiradicalar activity was evaluated by measuring the scavenger capacity of the DPPH radical. Phytochemical analyzes of the extract were performed by thin layer chromatography and HPLC-PDA. The aqueous extracts of Klainedoxa gabonenis and Tephrosia vogelii showed antiproliferative activity against U87-MG cancer cells with IC50 values below 90 μg / ml. The aqueous extract of Klainedoxa gabonenis also showed remarkable antiradical activity (IC50 = 4± 0,73 μg/ml). In addition, the treatment of U87-MG cancer cells by both the aqueous extract of Klainedoxa gabonensis (100 μg / ml) and by an MEK protein inhibitor (1 μM) causes a total suppression of U87-cell proliferation. MG (glioblastoma). HPLC-PDA analysis of the aqueous extract Klainedoxa gabonenis showed the presence of gallic acid compounds (41.9%) and Quercetin (2.17%).: Our study identified two medicinal plants with antiproliferative properties among the four Congolese herbal medicines evaluated, one with both anti-proliferative and antiradical properties.

No abstract