We report a case of femoral head osteonecrosis that originally was misdiagnosed as a femoral neck stress fracture by plain radiography and magnetic resonance imaging. The correct diagnosis was made using pinhole bone scintigraphy, which revealed a completely cold lesion of the entire femoral head, confirmed by histologic examination. The patient was treated with muscle pedicle bone grafting, and 3 months postoperatively, pinhole bone scintigraphy showed improved vascularity of the femoral head.
The purpose of this study was to evaluate the results of the authors' modification of Salter innominate osteotomy in Perthes' disease. The operation was performed in 16 hips of 15 Perthes' patients (11 boys and 4 girls). The posterior half of the ilium was cut by a Gigli saw using a conventional method. The anterior half was osteotomized using a reciprocal saw in a direction of 45 degrees obliquely to the coronal plane and 30 degrees to 40 degrees posteroinferiorly to the sagittal plane. Stable interposition of the bone block was achieved within the osteotomy site. Bone union occurred in all cases within 4 months without displacement of the osteotomy. The mean of the center-edge angle improved from a mean 19 degrees preoperatively to 29.4 degrees postoperatively, and the average epiphyseal extrusion improved from 23% to 9.5%. The modified Salter osteotomy provided much better stability by simply changing the direction of osteotomy.
Reaksi seluler kondrosit osteoartritis pada lutut ditandai dengan peningkatan sitokin tumor necrosis factor-α (TNF-α).TNF-α mengaktifkan fibroblas dan makrofag sinovial untuk menyekresi enzim degradasi dan menekan sintesis proteoglikan rawan sendi sehingga memberikan gambaran histopatologik kartilago yang mengalami perubahan. Osteoartritis sekunder terjadi akibat trauma sendi yang menyebabkan nyeri. Terapi obat seperti non-steroidal anti-inflammatory drugs (NSAIDs) yang digunakan menyebabkan efek samping merugikan jika digunakan dalam jangka panjang. Fraksinasi sarang semut papua (Myrmecodia pendans) diketahui memiliki kandungan salah satunya flavonoid yang berfungsi sebagai anti-inflamasi, antioksidan dan pelindung sel. Berdasar hal tersebut maka ingin diketahui potensi fraksinasi sarang semut papua pada osteoartritis kartilago lutut kelinci dalam menghambat enzim proinflamasi, yaitu TNF-α dan memberikan perbaikan secara histopatologik dibanding dengan kontrol. Penelitian menggunakan uji eksperimental hewan dengan desain experimental comparative menggunakan 8 kelinci ras New Zealand yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol dan kelompok yang diberikan fraksinasi sarang semut papua dengan dosis 2,5 mg/kgBB intra-artikular. Kemudian dilakukan pengukuran kadar TNF-α dan skoring secara histopatologik. Penelitian dilakukan di Fakultas Kedokteran, Universitas Padjadjaran periode Februari-Maret 2017. Pada Uji-t tidak berpasangan untuk TNF-α didapatkan nilai p=0,011; Uji Mann Whitney untuk skoring histopatologik dengan nilai p=0,034 pada kelompok yang diberian fraksinasi sarang semut papua. Terdapat penurunan TNF-α dan perbaikan secara histopatologik pada kartilago osteoartritis lutut kelinci yang diberikan fraksinasi sarang semut papua.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.