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CitationSingh A, Boyat AV, Sandhu JS. Effect of a 6 week plyometric training program on agility, vertical jump height and peak torque ratio of Indian Taekwondo Taekwondo demands for quick change in direction while keeping balance, strength, speed and body control through high level of lower limb strength, agility to improve performance. Methodology: 30 elite national level male Taekwondo players (mean age 22.0±1.6 years; mean Height, 174.4±4.4; mean mass 62.4±6.9 kg, training experience were 21±2.29 years, 5±1.70 years respectively) were divided into two groups, G1 (n=15) has undergone plyometric training for 6 weeks and G2 (n=15) control group. Before and before after 6 weeks all subjects underwent for Illinois agility test, vertical jump by kinematic measurement system t and isotonic muscles (Hamstrings -quadriceps) peak torque ratio by isokinetic dynamometer. Result: After 6 week of plyometric training program agility, vertical jump height and peak torque ratio was improved significantly (p<0.05) in G1 group (plyometric training group). No significant changes found in G2 group (control group). Conclusion: Improvement in agility, vertical jump and peak torque ratio of taekwondo players occur after 6 week of plyometric training which will reducing the risk of lower limb injuries.

Aim: The current investigation is focused on solid self-microemulsifying drug-delivery systems (S-SMEDDS) of mefenamic acid (MFA) for improving pharmacodynamic activity. Methodology & results: Solubility assessment in various lipid excipients and optimization of pseudoternary plots were carried out for development of liquid SMEDDS. The optimized liquid SMEDD formulation was spray dried to solid dosage form and observed with enhanced amorphization or molecular dispersion of MFA in S-SMEDDS, as evident from x-ray diffractometry and differential scanning calorimetry studies. Enhanced in vitro dissolution rate of optimized formulation was observed, resulting in multifold enhancement in absorption profile of MFA, as compared with pure drug and marketed product. These studies further substantiate the dose reduction in SMEDDS by gaining equivalent therapeutic profile with marketed product. Enhanced analgesic and anti-inflammatory activity was observed with S-SMEDD formulations in acetic acid-induced writhings and carrageenan-induced paw edema models, respectively. Conclusion: The optimized S-SMEDD formulation holds great promise for enhancement of its physiochemical and biological attributes.