T HE PRESENT study focused on synthesis of radioiodinated aniracetam for a potential brain imaging. Aniracetam (AN) has been labeled using [ 125 I] with chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to get high radiochemical yield of the radioiodinated aniracetam. The obtained results show a high radiochemical yield of iodoaniracetam that reached 98%. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoreses and high performance liquid chromatography (HPLC). Docking and modeling with AMPA receptors, gamma camera and drug inhibition were studied. In vivo biodistribution of radioiodinated aniracetam was evaluated in Swiss albino mice. The biodistribution results show a brain uptake that reached 9.50 ± 0.17 %ID/g at 15 min post injection (p.i.). Based on these results, it can be stated that radioiodinated aniracetam could be efficiently used as a potential radiotracer drug for brain imaging.

combination on irradiated jaw bones in rats through radiographic assessment of the bone density and histopathologic examination of bone morphology. Forty male albino rats were divided randomly into 4 groups each of 10 rats. Group R represented the rats that received fractionated radiation dose (2 Gray per fraction) for one week. Groups LR, eR and LeR represented the rats that received L-Carnitine 300mg/kg via intra peritoneal injection, vitamin e 40mg/kg via intramuscular injection or both daily for five days and then exposed to fractionated radiation 2 Gray day after day for one week after the last treatment, respectively. Data revealed a significant improvement of mandibular bone density in the groups received L-Carnitine, vitamin e alone or in combination as compared to the gamma-irradiated group. moreover, the treated groups showed almost normal morphology of both mandibular bone and periodontal ligament in contrast to the gamma irradiated group where bone resorption and periodontal ligament degeneration and vacuolization were detected. In conclusion, gamma radiation had a deleterious effect on mandibular bone and periodontal ligament as indicated by decreased bone density and altered morphology. In addition, L-Carnitine and vitamin e treatment alone or in combination could, to a large extent, maintain the normal bone density and preserve the morphological architecture of mandibular bone and periodontal ligament.

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