Improved survival in patients with locally advanced prostate cancer treated radiotherapy and goserelin Bolla, M.; González González, D.; Warde, P.; Dubois, J.B.; Mirimanoff, R-O.; Storme, G.; Bernier, J.; Kuten, A.; Sternberg, C.; Gil, T.; Collette, L.; Pierart, M.

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Relationship between thermal dose and outcome in thermoradiotherapy treatments for superficial recurrences of breast cancer: data from a phase III trial Sherar, M.; Liu, F.F.; Pintilie, M.; Levin, W.; Hunt, J.; Hill, R.; Hand, J.; Vernon, C.; van Rhoon, G.; van der Zee, J.; González González, D.; van Dijk, J.D.P.; Whaley, J.; Machin, D. Published in:International Journal of Radiation Oncology Biology Physics DOI:10.1016/S0360-3016(97)00333-7 Link to publicationCitation for published version (APA): Sherar, M., Liu, F. F., Pintilie, M., Levin, W., Hunt, J., Hill, R., ... Machin, D. (1997). Relationship between thermal dose and outcome in thermoradiotherapy treatments for superficial recurrences of breast cancer: data from a phase III trial. International Journal of Radiation Oncology Biology Physics, 39, 371-380. https://doi.org/10.1016/S0360-3016(97)00333-7 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Purpose: The objective of this study was to determine whether the thermal tmtments and other thermal Pactors correlate with outcome after combined carcinoma recurrences. Data were from the combined hyperthermia and radiation tmktment arms 0Pfour PhaseResuits: Five thermal parameters were tested, ail associated with the iow regions of the measur4 &@&tions. Max(TDmin) and Sum(TDmin) were associated with c rawrs representative of the low end of the measured temperature complete response rate, local disease-free survival, time to local failure and overail survival. 0 1997 Elsevier Science Inc.Hyperthermia, Randomized trial, Thermal dose, Outcome, Breast cancer, Recurrence. INTRODUCTIONWe recently reported that hypeitheimia is an effective adjunct to radiation in the treatment of chest wall recnrrences of breast carcinoma (1 I). This result is consistent with that of a recent trial of the effect of hypertherrnia on the response of malignant melanoma (19) and neck node metastases from head and neck cancer (27). However, other studies have shown no benefit in the addition of hyperthermia to radiation either for the treatment of chest wall recumnces of breast cancer using external heating (22,23), or for interstitial heating of miscellaneous tumors (9)

The combined result of the five trials has demonstrated the efficacy of hyperthermia as an adjunct to radiotherapy for treatment of recurrent breast cancer. The implication of these encouraging results is that hyperthermia appears to have an important role in the clinical management of this disease, and there should be no doubt that further studies of the use of hyperthermia are warranted.