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IntroductionScrub typhus is a vector borne zoonotic disease caused by Orientia tsutsugamushi, endemic to tsutsugamushi triangle. As the characteristic eschar is not always present, laboratory testing especially serological assay are the main stay of diagnosis. Materials and methodsA total of 346 well-characterized sera from normals and patients with scrub typhus, malaria, dengue, enteric fever and gram negative septicaemia were tested for IgM antibodies by ST IgM ELISA and ST Ig M ICT ResultsThe sensitivity and specificity of Scrub typhus IgM ICT and ELISA were 98.7, 96.3 and 97.4, 99.3 respectively. The IgM ICT and ELISA had a excellent concordance (99%) and a very high negative predictive value. ConclusionThe findings from this study suggest that IgM ICT and IgM ELISA can be used interchangeably for serodiagnosis of scrub typhus in resource poor settings. Abbrevations-STIgM ELISA-Scrub typhus Detect IgM ELISA ST IgM ICT-Scrub Typhus Detect IgM rapid test (Immunochromotography test)

The study revealed the differential ability of cefepime/taniborbactam and cefepime/zidebactam in tackling carbapenemase-producing Indian clinical isolates that also harbored additional mechanisms of resistance. NDM-expressing E. coli with 4-amino-acid insert in PBP3 are predominately resistant to cefepime/taniborbactam, while the β-lactam enhancer mechanism-based cefepime/zidebactam showed consistent activity against single- or dual-carbapenemase-producing isolates including E. coli with PBP3 inserts.

Spotted fever group rickettsial (SFGR) infections are caused by a diverse group of intracellular bacterial species belonging to the genus Rickettsia (order: Rickettsiales, family: Rickettsiaceae). Within the family of Rickettsiaceae, SFGR infections are commonly distinguished from two other main groups of rickettsioses, i.e., the typhus group (Rickettsia typhi) and the scrub typhus group (Genus Orientia) [1,2]. SFGR are mainly transmitted by ticks, mostly hard ticks that feed on animals and humans. They comprise over 30 different Rickettsia species, of which at least 21 are pathogenic