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Encapsulation of ICG and IR-1061 in PCL–PEG micelles producing agents with increased stability of ICG and tunable PTT and PDT activity. The micelles are also useful for NIR imaging and NIR nanothermometry.

Multimodal imaging can provide multidimensional information for understanding concealed microstructures or bioprocesses in biological objects. The combination of over–1000 nm near–infrared (OTN–NIR) fluorescence imaging and magnetic resonance (MR) imaging is...

Fluorescence imaging in the over-thousand nanometer (OTN-) near-infrared (NIR) wavelength region is an emerging technique for real-time bioimaging. OTN-NIR probes are made from micellar nanoparticles encapsulating IR-1061 dye in the core of poly(ethylene glycol) (PEG) phospholipid (PL), such as 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-N-[methoxy PEG] micelles. The property investigation revealed that the probe is less stable in albumin and PBS while remaining unchanged in water and saline. The results are critical for applying OTN-NIR probe from DSPE-PEG micelles in physiological environments.