Rhododendron album Blume (RA) has traditionally been used as an herbal medicine and is considered to have anti-inflammatory properties. In the present study, we screened RA extracts with anti-inflammatory properties. The biological effects of an RA methanol extract (RAME) on inflammation were investigated in lipopolysaccharide (LPS)-stimulated mouse RAW264.7 cells. We investigated the effects of RAME on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW264.7 cells. To explore the anti-inflammatory mechanisms of RAME, we measured the mRNA and protein expression of pro-inflammatory mediators induced by RAME in the LPS-stimulated RAW264.7 cells by RT-PCR and western blot analysis, respectively. RAME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α in the LPS-stimulated RAW264.7 cells. It also suppressed the mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and mitogen-activated protein kinases (MAPKs) with a concomitant decrease in the nuclear translocation of nuclear factor-κB (NF-κB) in the LPS-stimulated RAW264.7 cells. These results indicate that RAME inhibits LPS-induced inflammatory responses. These effects were considered to be strongly associated with the suppression of NF-κB activation. We therefore suggest that RAME may be prove to be an effective therapeutic agent for the treatment of inflammatory diseases.

Due to the COVID-19 pandemic, the new normal has prioritized health and well-being among others through nature-based healing as offered by Perum Perhutani, a state-owned enterprise that manages forests in Java and Madura. Healing Forest or forest therapy is an activity to relieve stress, both physically and mentally, combining nature-based healing media and stress relieving activities. Due to the importance, one of the destinations managed by Perum Perhutani, namely Ranca Upas, was chosen as the pilot project of the Healing Forest Program. This study was aimed at determining healing treatments for relieving stress by utilizing the nature-based healing media through natural forest characteristic indicators. Data collection techniques were carried out through Focus Group Discussion (FGD) with a psychiatrist as determinants of treatments and also through modeling and direct simulations to acquire the results. The program focused on two main indicators: forest characteristics and stress relieving treatments for 10 participants. The simulation results show significant improvements in participants’ oxygen level absorption, blood pressure, and heart rate from pre-test until post-test. There were three base treatments used in the simulation. Those treatments decreased the blood pressure for the average 6.1% (there were 3 participants out of 10 experiencing a change from high-normal to normal blood pressure), decreased the heart rate per minute for the average 13.2% (with the result of post-test were good and very good heart rated) and increased the oxygen level for the average 3.1% (there were 4 participants out of 10 experiencing a change from mild hypoxemia to normal oxygen level). These findings provide healing treatments for relieving stress and anxiety by utilizing the nature-based healing media through natural forest characteristic indicators.

Speed Yamaha Enduro 15PK. Setelah dilakukan penelitian dan uji bahan terhadap roda gigi yang sudah rusak dan dilakukan perbandingan dengan roda gigi yang masih baru ternyata roda gigi yang sudah dipakai mengalami penurunan beberapa perubahan struktur dan sifat bahan, terutama hasil uji komposisi kimia dapat di analisa bahwa bahan roda gigi yang sudah di pakai mengalami penurunan sifat bahan sehingga bahan tersebut menjadi lebih rendah terutama nilai kandungan Si (kekuatan baja) roda gigi yang sudah rusak yaitu 0,246% sedangkan yang masih baru (belum di pakai) 0,359% dan kandungan lainnya dapat dilihat di bab IV tabel hasil uji komposisi kimia. Perlu juga diperhatikan sistem perawatan pada mesin speed yamaha enduro termasuk pergantian oli, perawatan setelah operasi, dan beban dalam pemakaian juga perlu diperhatikan agar mesin bekerja lebih ringan dan tidak terjadi pemaksaan terhadap kerja mesin sehingga roda gigi mudah pecah dan sebagainya. Kata kunci : Mesin speed yamaha enduro 15PK, roda gigi maju mundur, alat uji lab dan buku referensi.

This study aims to determine the effect of cash holding, profitability (ROA), financial leverage (DER) on firm value (PBV) with earnings management as a moderating variable in manufacturing companies listed on the Indonesia Stock Exchange. The sample of this research is 24 companies in the manufacturing sector with a research period from 2015-2020. The data analysis technique used in this study is moderated regression analysis (MRA). The results showed that cash holding and earnings management did not affect firm value (PBV). Profitability, as measured by return on assets (ROA) and financial leverage as measured by debt to equity ratio (DER), has a significant positive effect on firm value (PBV). The results also conclude that earnings management does not have a moderating role in the effect of cash holding, profitability (ROA), financial leverage (DER) on firm value (PBV).

program TV merupakan sebuah acara yang banyak di tonton orang adalah untuk dapat dinikmati dalam bentuk audio visual. Menariknya sebuah acara TV bergantung pada kemasan. Pada penelitian ini dibahas mengenai bagaimana mengemas sebuah acara TV agar terlihat menarik menggunakan teknik editing kinetic typography. Penelitian ini tentang pembuatan progam acara TV yaitu program acara Anak Kampus. Hasil dari penelitian ini adalah program acara anak kampus yang akan ditayangkan di charlita TV, TV local di Pandeglang, Banten