Background: Avocado is a plant that can grow in tropical climates. In general, people only consume the fruit while the skin and seeds are not used. Avocado fruit, skin and seeds contain secondary metabolites such as flavonoids and tannins which have antioxidant activity. Objective: To determine antioxidant activity, total flavonoid, and total tannin content of the ethanol extract of avocado peel. Methods: P. americana Mill. was collected from Lubuk Linggau, South Sumatra. The ethanol extract of P. americana Mill. peel obtained by maceration with ethanol. Qualitative analysis of flavonoids using Mg and HCl while tannins using FeCl3. Determination of total flavonoid content was carried out with AlCl3 reagent and Folin-Ciocalteu reagent to determine the total tannin content and was measured by a UV-Vis Spectrophotometer. Determination of antioxidant activity using the DPPH method. Result: The results of the qualitative analysis showed that ethanol extract of avocado peel contained flavonoids and tannins. It also had antioxidant activity with IC50 of 41,93 µg/mL. The total flavonoid and tannin content of it were 125,01 mgQE/g extract and 53,82 mgTAE/g extract respectively. Conclusion: Ethanol extract of avocado peel had antioxidant activity, while the total flavonoid compounds was higher than the total tannins. Keywords: antioxidant, DPPH, total flavonoid, total tannins

Research has been conducted on the description of the use of chemotherapy drugs and evaluation of the suitability of doses with the method of body surfeace area (BSA) in breast cancer patients (ca.mamae) at the Sekayu Regional General Hospital. The purpose of this study is to find out an overview of the use of drugs and doses given in chemotherapy patients. This research is descriptive with retrospective data retrieval method where data is obtained from the medical records of patients diagnosed with breast cancer in the period January-December 2019. Data retrieval technique in the form of total sampling, obtained 18 samples according to inclusion criteria.The results of the study obtained is on the use of chemotherapy drugs all patients get fac drug regimen as many as 18 patients (100%) and evaluation of dose conformity calculation obtained by 17 patients (94.44%) obtained an inappropriate dose and 1 patient (5,56%) get the appropriate dosage. From the results of the study obtained that the chemotherapy drug used is a first-line chemotherapy drug is in accordance with the treatment guidelines and the dose used has not been in accordance with the calculation based on the body surface area (BSA).