The advanced molybdenum-based rare process experiment (AMoRE) aims to search for neutrinoless double beta decay ($$0\nu \beta \beta $$0νββ) of $$^{100}$$100Mo with $$\sim 100\,\hbox {kg}$$∼100kg of $$^{100}$$100Mo-enriched molybdenum embedded in cryogenic detectors with a dual heat and light readout. At the current, pilot stage of the AMoRE project we employ six calcium molybdate crystals with a total mass of 1.9 kg, produced from $$^{48}$$48Ca-depleted calcium and $$^{100}$$100Mo-enriched molybdenum ($$^{48{{\text {depl}}}}\hbox {Ca}^{100}\hbox {MoO}_{4}$$48deplCa100MoO4). The simultaneous detection of heat (phonon) and scintillation (photon) signals is realized with high resolution metallic magnetic calorimeter sensors that operate at milli-Kelvin temperatures. This stage of the project is carried out in the Yangyang underground laboratory at a depth of 700 m. We report first results from the AMoRE-Pilot $$0\nu \beta \beta $$0νββ search with a 111 kg day live exposure of $$^{48{{\text {depl}}}}\hbox {Ca}^{100}\hbox {MoO}_{4}$$48deplCa100MoO4 crystals. No evidence for $$0\nu \beta \beta $$0νββ decay of $$^{100}$$100Mo is found, and a upper limit is set for the half-life of $$0\nu \beta \beta $$0νββ of $$^{100}$$100Mo of $$T^{0\nu }_{1/2} > 9.5\times 10^{22}~\hbox {years}$$T1/20ν>9.5×1022years at 90% C.L. This limit corresponds to an effective Majorana neutrino mass limit in the range $$\langle m_{\beta \beta }\rangle \le (1.2-2.1)\,\hbox {eV}$$⟨mββ⟩≤(1.2-2.1)eV.

The AMoRE (Advanced Mo-based Rare process Experiment) project is a series of experiments that use advanced cryogenic techniques to search for the neutrinoless double-beta decay of 100 Mo. The work is being carried out by an international collaboration of researchers from eight countries. These searches involve high precision measurements of radiation-induced temperature changes and scintillation light produced in ultra-pure 100 Mo-enriched and 48 Ca-depleted calcium molybdate ( 48depl Ca 100 MoO 4 ) crystals that are located in a deep underground laboratory in Korea. The 100 Mo nuclide was chosen for this 0νββ decay search because of its high Q-value and favorable nuclear matrix element. Tests have demonstrated that CaMoO 4 crystals produce the brightest scintillation light among all of the molybdate crystals, both at room and at cryogenic temperatures. 48depl Ca 100 MoO 4 crystals are being operated at milli-Kelvin temperatures and read out via specially developed metallic-magnetic-calorimeter (MMC) temperature sensors that have excellent energy resolution and relatively fast response times. The excellent energy resolution provides good discrimination of signal from backgrounds, and the fast response time is important for minimizing the irreducible background caused by random coincidence of two-neutrino double-beta decay events of 100 Mo nuclei. Comparisons of the scintillating-light and phonon yields and pulse shape discrimination of the phonon signals will be used to provide redundant rejection of alpha-ray-induced backgrounds. An effective Majorana neutrino mass sensitivity that reaches the expected range of the inverted neutrino mass hierarchy, i.e., 20-50 meV, could be achieved with a 200 kg array of 48depl Ca 100 MoO 4 crystals operating for three years.

The first phase of the Advanced Mo-based Rare Process Experiment (AMoRE-I), an experimental search for neutrinoless double beta decay (0$\nu\beta\beta$) of $^{100}$Mo in calcium molybdate (CMO) crystal using cryogenic techniques, is in preparation at the YangYang underground laboratory (Y2L) in South Korea. A GEANT4 based Monte Carlo simulation was performed for background estimation in the first-phase the AMoRE-I detector and shield configuration. Background sources such as $^{238}$U, $^{232}$Th, $^{40}$K, $^{235}$U, and $^{210}$Pb were simulated from inside the crystals, surrounding materials, outer shielding walls of the Y2L cavity. The estimated background rate in the region of interest was found to be $< 1.5 \times 10^{-3}$ counts/keV/kg/yr (ckky). The effects of random coincidences between background and two-neutrino double beta decay of $^{100}$Mo were estimated as a potential background source and its estimated rate was $< 2.3 \times 10^{-4}$ ckky

Background To evaluate the temporal changes of diffusion tensor imaging (DTI) indices, T2 values, and visual signal intensity on various fat suppression techniques in the early state of denervated skeletal muscle in a rat model. Methods Institutional Animal Care and Use Committee approval was obtained. Sciatic nerves of eight rats were transected for irreversible neurotmesis model. We examined normal lower leg and denervated muscles at 3 days, 1 week, and 2 weeks on a 3 Tesla MR. fractional anisotropy (FA), mean apparent diffusion coefficient (mADC), and T2 values were measured by using DTI and T2 mapping scan. We subjectively classified the signal intensity change on various fat suppression images into the following three grades: negative, suspicious, and definite change. Wilcoxon‐sign rank test and Kruskal‐Wallis test were used for the comparison of FA, mADC, T2 values. McNemar's test was used for comparing signal intensity change among fat suppression techniques. Results FA values of denervated muscles at 3 days (0.35 ± 0.06), 1 week (0.29 ± 0.04), and 2 weeks (0.34 ± 0.05) were significantly (P < 0.05) lower than that in the control group (0.54 ± 0.17). mADC of denervated muscles decreased without statistically significant (P > 0.05) change. T2 values were significantly increased at 1 week (38.11 ± 6.42 ms, P = 0.017) and markedly increased at 2 weeks (46.53 ± 5.17 ms, P = 0.012). The grade of visual signal intensity change on chemical shift selective fat saturation, STIR and IDEAL images were identical in all cases (P = 1.000). Conclusion FA and T2 values can demonstrate the early temporal changes in denervated rat skeletal muscle. J. Magn. Reson. Imaging 2015;42:617–623

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