ABSTRACT:Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel 18 F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [ 18 F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [ 18 F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection. In addition, the possible mechanisms of [ 18 F]FA3OP for necrotic myocardium were discussed. The results showed [ 19 F]FA3OP may bind DNA to achieve targetability to necrotic myocardium by intercalation. In summary, [ 18 F]FA3OP was a more promising "hot spot imaging" tracer for rapid visualization of necrotic myocardium.

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HA and o-HA manifested the regulatory impact on DSS-induced mice and LPS-evoked caco-2 cells, and o-HA had improved outcomes.

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