Trifluoroethyl (CH2CF3) is an important functional group in many pharmaceutical and agrochemical compounds. Herein, we report an efficient method for the copper-catalyzed direct trifluoroethylation of heteroarenes. The reaction exhibited good compatibility to various substrates, and the desired products were obtained in good yields. Preliminary mechanistic investigations indicate the trifluoroethyl radical is involved in the catalytic circle. Moreover, the late-stage modification of bioactive molecules further confirmed the practical applications of this method.

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A facile and efficient protocol has been developed for the synthesis of fused 4H-pyran derivatives via one-pot three components combination of aldehydes, 1,1-bis(methylthio)-2-nitroethylene (BMTNE), and enolketone/dimedone derivatives under the catalysis of FeCl 3 . The target products could be obtained in moderate to good yields.