Recently, Ganshorn and Kurz 5 reported that the plasma binding of the su1£onamide drugs, su1£amethoxidiazine and su1£ame-thoxine, was greater in adult plasma than in plasma from cord blood. Since the su1£on-amides are bound mainly to plasma albumin, l we investigated the interaction of sulfaphenazole with albumin isolated by starch block electrophoresis from cord plasma and from the plasma of neonates and adults. Our results show that sulfaphenazole has a lower affinity for plasma albumin isolated from cord and neonatal blood than for adult human plasma albumin. However, this reduced affinity ap-

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their ability to induce ataxia, to decrease locomotor activity, and to afford protection against electroshockand strychnine-induced convulsions in mice. In general, the compounds described herein failed to afford protection at an acceptable dose (<50 mg/kg) against convulsions induced by either method. However, many compounds induced ataxia, as judged by impairment of ability to traverse a suspended rod, and decreased motor activity. The data for the more interesting compounds are summarized in Table I; comparable data for Mannich base 1 are included.