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Hematopoiesis is a lifelong cell renewal process regulated by a family of lineage specific hematopoietic growth factors. Several hematopoietic growth factors such as G-CSF, GM-CSF, and M-CSF have been clinically evaluated for enhancement of host defense in normal and immunocompromised patients and for the treatment of infectious diseases. This paper reports the structure-activity relationships of low molecular weight hematoregulatory peptides based on a nonapeptide (1, SK&F 107647). Like the macromolecular growth factors, these peptides modulate host defense. A molecular target for this class of compounds has not yet been identified. However, the structure-activity relationships established by this study implicate a very specific molecular recognition event that is pivotal for the biological activities of 1 and its analogues.

and other references cited in this review. (2) Bhatnagar, P. K.; Agner, E.; Alberts, D.; Arbo, B. A.; Callahan, J.; Cuthbertson, A.; Engelsen, S. J.; Hartmann, M.; Heerding, D.; Hiebl, J.; Huffman, W. F.; Hysben, M.; Fjerdingstad, H.; King, A. K.; Kwon, C.; Kremminger, P.; LoCastro, S.; Løvhaug, D.; Pelus, L. M.; Petteway, S.; Takata, J.

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