The lab-on-chip testing units based on microfluidics technology are booming nowadays, due to robustness, simplicity of use and reliability. Multilayer ceramics, functionalized with nano-scaled sensing materials, and further integrated within microfluidic test elements, are of great challenge and represent the purpose of the paper. The LTCC technology versatility allows the 3D integration of electrochemical sensors with microfluidic features, and further with advanced signal processing and wireless communication.This full text paper was peer-reviewed at the direction of IEEE Instrumentation and Measurement Society prior to the acceptance and publication.978-1-4799-6477-2/15/$31.00 ©2015 IEEE

Post-stroke aphasia is an important topic in clinical rehabilitation neurology, affecting a significant number of stroke patients worldwide each year. Although the anatomical basis of aphasia has been explored for over a century, a revision of disease classification has led to a broader understanding of the subject and has stimulated the field of drug development to yield novel therapies. In this context, the authors commence the current narrative review by presenting the widely accepted aphasia classifications and the corresponding management practices. Subsequently, speech-language therapies are presented, with a focus on the widely preferred patient-centered approach. We conclude with a brief discussion regarding adjunctive treatment options such as pharmacological intervention, non-invasive brain stimulation techniques, and virtual reality rehabilitation.

Cerebral venous thrombosis in pediatric patient has a varied etiology. The authors present the case of a teenager who, since the debut of SARS-CoV-2 infection, has accused intermittent right side hemicrania, which has become persistent in association with nausea and vomiting since the 5th day of quarantine. She was hospitalized in the 9th day since the debut. Neuroimaging revealed extended venous cerebral thrombosis affecting the right sigmoid sinus, the transverse sinus bilaterally, the confluence of the transverse sinuses and the right internal jugular vein. The evolution was favorable under anticoagulant and symptomatic treatment. Laboratory tests excluded other etiological causes for the cerebral venous thrombosis, thus the authors consider that cerebral thrombosis is a possible complication of SARS-CoV-2 infection in teenagers.

In order to increase the quality of life of patients with epilepsy, it is essential to develop tools that facilitate early disease diagnosis and encourage the use of individualized therapies. The association between seizures and other neurological pathologies is well known but incompletely explained, with multiple sclerosis (MS)-seizures correlation being a relevant example. In this context, the present review aimed to highlight the most important facts related to the association between the heterogeneous group of epileptic pathology and MS, in order to provide initial directions for establishing a diagnostic and therapeutic protocol. The first part reviewed the most relevant epidemiological and clinical data on seizures; MS association. Subsequently, it highlighted the most common and actually accepted pathophysiological mechanisms that try to explain the association between the two pathologies. Finally, the importance of paraclinical investigations and the optimal choice of antiseizure-based therapies with respect to seizures associated with MS are presented, also revealing several directions that should be explored in the near future. Contents 1. Introduction 2. Methodology and method 3. Epidemiological data revealing a significant association between MS and seizures 4. Relevant aspects of seizures in patients with MS 5. Pathophysiological mechanisms (incompletely) explaining the MS-epilepsy association 6. The role of imagistic techniques in studying the MS-epilepsy association 7. Neurophysiology in patients with MS with epilepsy-in search of specific patterns 8. Individualized ASMs treatment and prognosis in patients with MS with epilepsy 9. Conclusions