The Center for Regional Innovation and Business Acceleration of Southern Sonora has requested assistance in preparing its strategic plan for the next five to ten years of its evolution. The objective was achieved by generating 11 strategic initiatives. The concepts of mega planning and economic complexity were used, which follow a 9‐step procedure: (1) the organization's external context research; (2) evaluation model and tool design; (3) application of the evaluation model; (4) analysis of strengths, weaknesses, opportunities, and threats; 5) strategy, mission objectives, and value proposals; (6) strategic objectives; (7) strategy map; (8) balanced scorecard; and (9) strategic projects. The findings provide a variety of theoretical and methodological contributions, including the combination of mega planning and economic‐complexity theories, models, and tools. After that, the researchers developed an acceleration model and its data‐collection tool to measure small and medium‐sized enterprises' competitive advantages in the knowledge economy. In addition, the definition and alignment of the objectives and their key performance indicators for each level of the organizational‐elements model resulted in a strategy map and a balanced scorecard. The case study's purpose is to understand the relationship between strategic planning and the theory of economic complexity in order to offer valuable solutions to the relevant parties.