We describe a network sharable, interactive computational tool for rapid and sensitive search and analysis of biomolecular sequence databases such as GenBank, GenPept, Protein Identification Resource, and SWISS-PROT. The resource is accessible via the World Wide Web using popular client software such as Mosaic and Netscape. The client software is freely available on a number of computing platforms including Macintosh,

Protein secondary structure is conventionally identified using characteristic ranges of two backbone torsional angles r#J and $. We suggest that the secondary structure can be adequately characterized by a single descriptor, the Oi-lCi-IC,O, (where i is the residue number) pseudotorsional backbone angle.A set of 102 structurally distinct protein chains from the Protein Data Bank was used to evaluate the adequacy of this descriptor. We find that a specific range of OCCO angles corresponds to each major secondary structure. The complete range of OCCO angles (-180" to 179") was broken into 18 consecutive subranges of 20" each, and each subrange was assigned a letter. Thus, the OCCO profiles for each protein in the database were "translated" into a sequence of letters.The Needleman-Wunsch primary sequence alignment algorithm was then used for secondary/tertiary structure comparison and alignment. Preliminary results indicate that this new approach has a significant potential for rapid identification of fold families in the Protein Data Bank.

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This paper demonstrates the feasibility and potential of applying empirical mode decomposition (EMD) to forecast the arrival time behaviors in a parallel batch system. An analysis of the workload records shows the existence of daily and weekly patterns within the workload. Results show that the intrinsic mode functions (IMF), products of the sifting/decomposition process of EMD, produce a better prediction than the original arrival histogram when used in a simple weight-matching prediction technique. Promising applications include the implementation of an EMD/neural network combination.