Objectives: The research aimed to explore the aggression and coping strategies in Type A and Type B cardiac patients. The study also assesses the role of gender and personality type in cardiac patients. Methodology: 101 cardiac patients from different hospitals in Punjab having male (56) and females (45) with an average range of 22-70 were taken for the study. The education range was between middle to master and all were married. All the patients diagnosed with coronary heart disease were referred by their medical staff, with the problems in their ECGs, Echocardiography, and further diagnostic assessments taken as sample. Personality types, and coping styles have been assessed along with their detailed demographics. Results: The mean age range was 45 years, out of the total 101 patients male and female were 55.5% and 44.5%, respectively. Patients of type A and type B personality were 55(45.8%) and 46 (38.3%) respectively. In Cardiac patients avoidant Coping predicted verbal aggression and problem-focused coping predicted physical aggression whereas Problem-Focused and Avoidant Focused negatively predicted aggression among Type A cardiac patients. Gender moderated between aggression and personality type among type A and type B cardiac patients. The interaction effect of gender and personality type on problem-focused, emotion-focused, and avoidant-focused coping is also evident in the results. Conclusion: The study concluded that cardiac patients differ in their coping styles relevant to gender and personality type. Furthermore, gender also affects their level of aggression with the interaction of coping styles among them.