Introduction: Pregnancy is characterized by sequence of dynamic physiological changes that impact on multiple organ system functions and is associated with various changes in pulmonary anatomy and physiology. The aim of the study was to see whether any changes occur in pulmonary function tests in the three trimesters of pregnancy as compared with that of' control group. Material & Methods: A case control study of the pulmonary function tests were carried out in different trimester of pregnancy, on 70 normal pregnant women from 16 to 30 years attending antenatal clinic at Govt. Medical College, Nanded. Four respiratory parameters FVC, FEV1, FEV3, MVV & PEFR were determined in both, 70 pregnant women as cases & control group of 30 non-pregnant women of same age groups, Using computerized Medspiror instrument. Results: Expiratory Reserve Volume (ERV) and mean residual Volume (RV) in the pregnant subjects as the pregnancy advances reaching its maximum decrease by the end of III trimester. Mean Tidal Volume progressively increased as pregnancy advances reaching its maximum value at term , there is a gradual increase in the mean Minute Volume (MV) of the pregnant subjects as they proceed to term when compared with the controls. The mean Vital Capacity (VC) of the subjects in the I trimester pregnancy showed a non significant increase of 3.48 % The same parameter relating to the subjects in the II and III trimester pregnancy showed a statistically significant increase of 3.50 % and 8.60% respectively as compared with control subjects. Conclusion: Comparative study of pulmonary function tests on different trimesters of pregnancy showed that respiratory parameters were significantly compromised during pregnancy, There were decrease in respiratory parameters from first to third trimesters of pregnancy may be due to poor nutrition because all the subjects coming from middle class and poor socioeconomic status

Introduction: Menstrual cycle is an integral part of a woman's life. During these different phases, rhythmic changes occur in the levels of ovarian hormones especially progesterone and estrogen. The goal of this study was to study the effect of the luteal and follicular phases of the menstrual cycle on bronchial reactivity (BR) in a group of women. Material and Methods: The fifty girl medical students of first year MBBS of 18-24 years age were undertaken to study pulmonary function tests in different phases of menstrual cycle. Pulmonary function tests were taken between 8-10 th day of menstrual cycle, that is in follicular phase and again were recorded between 20-22 nd day of menstrual cycle that is in luteal phase by using spirometric technique. The results were expressed as Mean ± Standard Deviation (Mean+ SD). Statistical analysis was done through Graph pad prism. Comparison of pulmonary function parameters in different phases of menstrual cycle was done by using one way ANOVA (Analysis of Variance) by bonferroni post-hoc test. Results: Anthropometric measurement of all subjects in which mean age was 19.45 ± 1.80 years, arm span was 157.25± 6.37 cm, chest circumference was 80.58 ± 7.69 cm, height was 149.07 ±4.64 cm , weight was 45.65±6.69 Kgs. Spirometric study found FVC, FEV1, and PEFR increase in luteal phase of menstrual cycle compared to follicular phase, which were statistically significant. Conclusion: We found better lung functions which were statistically significant in luteal phase as compared to follicular phase of our subjects indicating a possible role of progesterone causing β adrenergic stimulation / sensitization.