This study indicates that silodosin was significantly effective, well tolerated and safe in patients who have voiding dysfunction associated with neurogenic bladder.

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Background : For the detection of transitional cell carcinoma (TCC) of the bladder, we compared the sensitivities and specificities between the ThinPrep test and Melanoma Antigen Gene (MAGE) test with voided urine (V), drained urine (D), and irrigated urine (I).Methods : We randomly selected 10 patients of a non-cancer group and 20 patients of a cancer group. V, D, and I were obtained preoperatively, and equally divided into two parts for the ThinPrep test and MAGE reverse transcriptase polymerase chain reaction (RT-PCR). The cystoscopic finding was used as the reference standard for detection of bladder cancer. The results of ThinPrep test and MAGE RT-PCR were compared according to cancer grade and stage.Results : The overall sensitivities of ThinPrep test were 45%, 85% and 85% for V, D, and I, respectively, while those of MAGE test were 50%, 85%, and 65%. Detection rate from drainage urine was considerably higher than that of voided urine in both methods (P<0.05). The specificities were 100% for all types of urine specimens with ThinPrep test and 100%, 90%, and 90% for V, D, and I, respectively, using MAGE test, without any statistically significant differences.Conclusions : For the detection of bladder cancer, MAGE RT-PCR and ThinPrep test showed a comparable sensitivity and specificity, and drained urine revealed the best detection rate. MAGE RT-PCR might be utilized as another marker of bladder cancer using urine specimens. (Korean J Lab Med 2007;27:50-5)

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Purpose: Lower urinary tract symptoms (LUTS) in taxi drivers may be associated with many years of driving or bad voiding habits such as excessive inhibition of voiding and repetitive bladder over-distension. This condition may be treated under the false impression that the patient is suffering with benign prostatic hyperplasia or prostatitis. In this study, the urodynamic data of taxi drivers with LUTS were analyzed according to the storage and voiding symptom results. Materials and Methods: 45 patients who underwent urodynamic study were included in this study among all the taxi drivers who complained of LUTS and who were without benign prostatic hyperplasia, urethritis and a prostatitis history. All the patients took the International Prostate Symptom Score (IPSS) self-assessment test. We divided the patients into 2 groups according to the chief complaint of storage symptoms (group I, 21 cases) and voiding symptoms (group II, 24 cases). The age distribution, driving years and prostate size were similar between the 2 groups. Results: The IPSS were 14.47±4.82 in group I and 13.91±3.49 in group II. Group II had larger maximal cystometric capacity than did group I (p 0.05). 4 cases of idiopathic detrusor overactivity (IDO) were observed in group I (p 0.05). Group II had a lower mean maximal flow rate than group I (p 0.05). The post-voiding residual urine volume and detrussor pressure at maximal flow were similar between the groups. There were 17 cases of pseudo-detrusor-sphicter dyssynergia observed in group II and 7 cases observed in group I (p 0.05). Detrusor underactivity (DU) was observed in 3 patients of group II. Conclusions: There were abnormal findings such as IDO, bladder outlet obstruction (BOO) and DU on the urodynamic studies of the taxi drivers. IPSS is insufficient for the diagnosis of BOO and DU. Urodynamic study may be useful in establishing the correct diagnosis and treatment of taxi drivers. (Korean J Urol 2006;47:165-170) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ