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Summary. Purification of the brain hormone of Nereis diversicolor and Perinereis cultrifera (Annelida : Polychaeta) by high-pressure liquid chromatography (HPLC).Five thousand brains inhibiting gametogenesis in Nereis diversicolor and Perinereis cultrifera were extracted with cold methanol, giving a micromolecular fraction containing the whole of the inhibitory activity of the brains. This micromolecular fraction, fractionated (i) on Sephadex G 25 fine and (ii) on Sephadex G 25 superfine, gave an inhibitory peak (P 5) in organ culture.Fraction P 5, purified by high-pressure liquid chromatography, showed an area with the same biological inhibitory activity as the blank brains.Introduction.

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