Medication errors can cause serious adverse effects and potentially to evoke the fatal risk of the disease. Monitoring the safety and efficacy of the drug adequately can prevent the occurrence of adverse effect. The main aim of this study is to identify and intervene the prescribing and dispensing errors among the Outpatient General Medicine department. Across sectional interventional study was carried out at the General Medicine Out-patient Department. The patients who satisfied inclusion and exclusion criteria were enrolled after obtaining their consent. The required data was collected in the patient's prescription and different types of medication errors was identified and documented. During this study period we found 303 prescriptions with medication errors out of 544 prescriptions. Of the 303 prescriptions prescribing errors was 315(79%) and 85(21%) were dispensing errors. The most common type of medication error was prescribing error. It was absence of strength (35.9%), absence of dosage regimen (32.4%), wrong drug (79.8%). The most common type of dispensing error was required quantity not supplied (55.7%), dispensing wrong drug (32.8%). Occurrence of medication errors was common in Outpatient General Medicine Department in this tertiary care teaching hospital. A clinical pharmacist can play a major role in early detection and prevention of medication errors and thus can improve the quality of care to the patients. Educating the patients about the drugs and their importance of right use can be helpful in minimizing errors.
Anti-epileptic drugs (AEDs) are the primary therapeutic models for epileptic patients and have been demonstrated to control seizures, which decreases the morbidity and mortality associated with epilepsy. A large number of AEDs have become available for the management of epilepsy; many of these agents are now utilized for conditions other than epilepsy. This study was aimed in assessing the prescribing patterns of anti-epileptics in various diseases (both epilepsy and Non epilepsy), utilization pattern of AEDs as mono therapy/ poly therapy, to monitor and report different Adverse Drug Reactions (ADRs) with these AEDs. A prospective observational study was conducted among 250 AED used individuals. The collected data was analysed for AEDs utilisation patterns, ADRs associated with these AEDs, Naranjo's assessment scale was used to check the severity of ADRs and Central Drug Standard Control Organisation (CDSCO) form is used to report the identified ADRs to Pharmacovigilance Programme of India (PVPI). Out of 250 patients, seizures were most commonly observed diagnosis in males 178 (71.2 %). Majority of patients 47 (18.8 %) were in the range of 31-40 years of age group. Highest number of patients was from psychiatry 97 (38.8 %). Seizures were commonly diagnosed followed by alcohol dependent syndrome. Commonly prescribed AED was Phenytoin in 92 (27.87 %) patients and gum hyperplasia was most commonly observed ADR with Phenytoin. Phenytoin was most frequently prescribed AED followed by sodium valproate. As Phenytoin is enzyme inducing drug and will show nonlinear pharmacokinetics, therapeutic drug monitoring is essential.
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