Background: Ovarian malignancy is seventh most common cancer in women globally. With increase in longevity, the incidence of epithelial ovarian cancer is increasing and its etiopathology remains unknown. We present preliminary epidemiological findings to help prioritize research.Methods: Present epidemiological study is retrospective, descriptive study over two years. The collected data was analyzed using SPSS software for overall survival, with respect to stage of disease and histopathology type. Multivariate analysis was done to know independent risk factors.Results: 114 cases of primary ovarian epithelial cancer were analyzed. Patients' mean age at diagnosis was 52.1±8.96 years (median=52). 52.6% patients had stage III disease at first visit. Serous adenocarcinoma (85.05%) was the most prevalent type of histopathology followed by mucinous (7.1%), clear cell (6.1%) and Endometroid carcinoma (1.75%). Surgery followed by combination of taxane and platinum chemotherapy was first line treatment in 35%. The mean age at diagnosis was more with advancing stage (stage one 44±9.53 and stage four 55.35±9.74 years) but it was not statistically significant (p=0.098) Advancing age demonstrated poor survival (log-rank p=0.05) but survival was not significantly different in relation to histopathology (log-rank =0.629). On multivariate regression analysis age of patient (p=0.004), and stage of disease (p=0.005) were found to be independent risk factors while histopathology was not an independent risk factor (p=0.688) for survival.Conclusions: Research should be aimed to find tools for screening and early diagnosis as well as better therapeutic approaches for advanced epithelial ovarian cancer.

Background: Inflammatory Pseudotumor of ovary is a distinct benign entity characterized by the presence of spindle cells mixed with variable amount of lymphocytes and plasma cells. Female genital tract is an unusual location for xanthogranulomatous inflammation and if present usually involves the endometrium. xanthogranulomatous oophoritis is rare and only a handful of cases have been reported.Methods: At The Gujarat Cancer and Research Institute, Ahmedabad; a Regional Cancer Centre we came across two cases of Xanthogranulomatous oophoritis, a rare clinical condition. In view of the rarity of the clinical entity, the cases are summarized and discussed.Results: Xanthogranulomatous oophoritis is a rare clinical entity with very few reported cases. Its pathogenesis involves chronic inflammatory process of unknown origin. Pre-operative diagnosis has been challenging due to non-specific presenting symptoms and radiological imaging. Characteristic microscopic picture includes presence of well-differentiated spindle cells with variable amount of collagenous stroma and presence of inflammatory changes. Immunohistochemistry performed at our institute was found to be positive for CD 68, Vimentin and S-100 for xanthogranulomatous oophoritis.Conclusions: Data from radiological imaging for extra genital xanthogranulomatous inflammation is being extrapolated to determine a pre-operative diagnosis for xanthogranulomatous oophoritis of the genital tract. However, no pathognomic radiological findings are defined at present making histopathological diagnosis the mainstay for diagnosis of this condition. Immunohistochemistry panel markers play a helpful role in the diagnosis when in doubt. Surgery is the definitive mode of treatment providing a good prognosis post operatively.

The most common complication in pregnancy is Hypertension complicating 12-22% of all pregnancies. Among these pre-eclampsia is the leading cause constituting 10% of all pregnancies worldwide. In hospital practice in India, the incidence of pre-eclampsia varies from 5% to 15% and of eclampsia about 1.5%. According to WHO report 2008, eclampsia constitutes for 12% of all maternal deaths in developing countries. Thus it is important to study its Epidemiology and Management strategies. Settings and Design: Retrospective descriptive data based study. Materials and Methods: The data is collected after reviewing the medical records of all gravid women with hypertensive disorder of pregnancy who presented between July 2010-July 2014. Data was collected on predesigned, standardised proforma of National Eclampsia Registry. Statistical analysis used: Statistical analysis was performed using SPSS version 22. Data was expressed as Mean, percentages, proportions. Chi-square test was used to find association between various categorical variables. p-value <0.05 was considered to be statistically significant. Results: During the study period there were 22,591 deliveries. There were 1468 mild and severe preeclampsia cases and 309 imminent eclampsia and eclampsia cases. The proportion of Pregnancy Induced Hypertension (PIH) cases was found to be 7.85% and that of eclampsia 1.36%. 74.34% of the patients belonged to age group between 20-30 years. 69.11% patients were primigravidas with significant corelation to parity (p value <.00). 68.4% cases were unbooked with p value <.00. 84.3% cases presented between 29-36 weeks. 56.96% patients had headache and 28.48% had headache with vomiting as premonitory symptoms. 74.4% patients had antepartum, 9.14% intra partum and 16.46% postpartum eclampsia. Increasing proteinuria was significantly related to no. of convulsions (p <.05). Maternal complications were seen in 21.68% cases. Maternal deaths during study period due to eclampsia complications were 1.3%. Perinatal complications were seen in 19.41% babies; prematurity being most common (40%). Low birth weight was seen in 68.09% babies which was statistically significant (p value <0.00). There was no significant change in the incidence of eclampsia over four years. Conclusions: Present study highlights various risk factors for pre-eclampsia. Unbooked, young primigravida with significant proteinuria are at increased risk for pre-eclampsia-related morbidity and mortality. As doctor to patient ratio is below par, the role of ASHA workers is important. Government efforts to track all pregnancies will ensure adequate antenatal care especially to the socio-economically deprived and rural population. Doctors working in peripheral hospitals should have periodic training in the management of preeclampsia and eclampsia to avoid missed opportunities as well as better transport facilities to handle obstetric emergencies. Key Messages: As no change in incidence of eclampsia over years, ASHA workers to be trained to identify warning signs. Doctors working i...

Background: Ovarian neoplasms are a distinct entity in women health care and are increasingly contributing to morbidity and mortality among women. The burden is not only related to the increasing incidence but also to the varied pathological features depending on the tissue of origin and pathogenesis. The study was carried out to find the prevalence and determine the clinical presentation and histo-pathological distribution of ovarian neoplasms. Management options were also noted.Methods: It is a retrospective study carried out at Goa Medical College between January 2013 to December 2015. All patients diagnosed and treated for ovarian neoplasm were included in the study. Data was tabulated using Microsoft Excel and descriptive statistical analysis was carried out using SPSS version 23.Results: A total of 3111 patients were admitted in gynecology at Goa Medical College during the specified time period. Of these 358 cases were diagnosed with ovarian neoplasm. On histopathology 196 were benign tumors and 162 were reported to be malignant. Commonest presenting symptom was abdominal distention seen in 51.1% of the patients, pain in 44.4%, followed by dyspepsia in 26.85%. Epithelial tumors were most common (Benign - 39.3%, Malignant - 41%) followed by sex cord stromal tumors and germ cell tumors in 7.26% of cases.Conclusions: Surface epithelial tumors were most common neoplasm. An alarming high no. of malignant tumors (45.25%) was found in present study. 44.4% tumors presented in 41-50 years age group. Presenting complaints were vague and nonspecific leading to delay in diagnosis. Histological type correlates with prognosis; therefore, preponderance of histological type will guide treatment options and patient education with respect to epidemiology.

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