AIMS: To assess the epidemiological indicators and the state of oncological care for patients with breast cancer in the Krasnoyarsk Territory from 2011 to 2021. MATERIALS AND METHODS: The study presents an analysis of data in the Krasnoyarsk Territory from 2011 to 2021. Data processing was carried out using Microsoft Excel and Statistica 6.0 software products. The correlation between morbidity and mortality was assessed using Spearmans correlation analysis, and the result was considered statistically significant at a significance level of p 0.05. RESULTS: An analysis of the incidence of breast cancer in the Krasnoyarsk Territory from 2011 to 2021 showed an increase in the number of cases by 35.2%. The peak incidence falls on the age range of 5569 years. The mortality rate for the study period tends to decrease; 1-year mortality decreased from 9.3% to 5.1%. The level of early diagnosis increased to 76.4%, while the rate of advanced forms of breast cancer decreased from 33.5% to 23.6%. There is an increase in the number of patients with breast cancer, registered in the dispensary for 5 years or more, from 54.7% to 62.7%, due to the use of modern clinical recommendations, the use of long courses of adjuvant endocrine therapy (up to 10 years), a wide range and frequency of use of antitumor, including targeted drugs. Correlation analysis between morbidity and mortality rates for the Krasnoyarsk Territory revealed an average, moderate relationship the correlation coefficient (r=0.59; p 0.05). A direct average correlation was obtained between the proportion of newly diagnosed cases of breast cancer at stages III and IV and the 1-year mortality rate (r=0.64; p 0.05). A very strong relationship was found between newly diagnosed cases of breast cancer and diseases detected at early stages (r=0.97; p 0.05). CONCLUSION: The results obtained indicate the effectiveness of ongoing measures for the prevention and early detection of diseases.

Among the multiple primary malignant tumors, breast cancer is the most common and in most cases it is combined with the second mammary gland, uterine body, stomach, colon, skin and ovary. Breast angiosarcoma is a very rare disease with unfavorable prognosis. Radiation therapy to the area of the breast is considered to be the main risk factor for the radiation-induced angiosarcoma. Diagnosis is based on the clinical aspect, the results of morphological and immunohistochemical findings. There are no uniform standards for the treatment of this pathology; a surgical method, systemic therapy, and radiation therapy are used. The article presents a clinical case of a female patient born in 1952, who was diagnosed with synchronous multiple primary cancer in 2014: stage 2A left breast cancer (cT2N0M0); bladder cancer stage I (cT1cN0M0). After the complex treatment, the patient received adjuvant endocrine therapy with Tamoxifen. In December 2018, single bluish formations appeared in the area of the postoperative scar, followed by a rapid growth of formations on the skin within a month, with a tendency to merge and necrosis. The patient was sent for biopsy of the formations with suspected recurrence of the disease. Immunomorphological patterns correspond to the angiosarcoma in the skin of the mammary gland. A simple mastectomy was performed. After 3 months, growth of angiomyosarcoma in the soft tissues of the anterior chest wall continued. Excision of the tumor in the soft tissues of the chest was performed and the patient underwent postoperative course of radiation therapy with a single focal dose (SFD) 2.5 Gy, total boost isodose of 50 Gy. At follow-up examinations held from January to December 2021, there is no evidence for continued growth and recurrence of the disease. The presented clinical observation demonstrates the experience of diagnostics and treatment of radiation-induced angiosarcoma in the patient with multiple primary synchronous lesions of the breast and bladder.

Background: Anthropometry is one of the simplest and most accessible methods. Breast cancer is largely associated with anthropometric indicators, such as weight, body mass index, waist-to-hip ratio, and waist circumference. Aims: To examine the anthropometric and topometric characteristics of the mammary glands of patients with breast cancer. Materials and Methods: A total of 260 patients with breast cancer were examined from 2019 to 2021 in the Department of Onco-mammological Surgery of the A.I. Kryzhanovsky Krasnoyarsk Regional Oncological Dispensary. Anthropometric examination was conducted according to the classical method, and parameters such as height and weight were obtained. Organometric measurements were conducted according to the Body Logic System (Mentor Medical Systems B. V., USA), developed by Professor Dr. Hammond for Mentor, a silicone implant manufacturer. Results: In the study group, the average height, weight, and body mass index were 163 (158168) cm, 75 (6586) kg, and 28.96 (2432.87) kg/m2, respectively. A comparative analysis of the main anthropometric data of patients with breast cancer showed relatively higher body length values in the young adult group and conversely smaller values in women in the senile period, as well as the average body mass index and body mass index in the older group. In women, the average chest circumference of the mammary gland in the middle-aged group decreased by 9 cm in the older period and by 6 cm in the senile period. Similar changes were found in the chest circumference at the level of the nipples. In women, the average values in the middle-aged group decreased by 9.5 cm in the older period and by 4 cm in the senile period. The distance from the jugular notch to the nipple of the right breast showed significantly (p 0.05) higher values in the older group (by 6 cm) and senile group (by 4.7 cm) than in the young adult group and between the middle-aged group and older group (by 4 cm) and in the senile (by 2.7 cm) group. Similar changes were found on the left breast in the older group (by 5.75 cm) and senile group (by 5.25 cm) compared with young adult group and between the middle-aged group and older group (by 4 cm) and senile (by 3.5 cm) group. The distance from the level of the middle of the clavicle to the nipples showed significantly (p 0.05) lower values of the right and left mammary glands in the your adult group than in other age groups. The intermammary distance was significantly (p 0.05) greater in the middle-aged group (by 0.5 cm) than in the older and senile groups. Conclusion: Most studies on breast anthropometry focus on plastic surgery because clear anthropometric measurements of the breasts and their relative positions based on fixed skeletal and soft tissue landmarks are useful for assessing the condition of the patients preoperatively and for evaluating breast aesthetics postoperatively. Future studies in clinical practice should identify women with a high risk of breast cancer based on anthropometric parameters.