AIMS: To assess the epidemiological indicators and the state of oncological care for patients with breast cancer in the Krasnoyarsk Territory from 2011 to 2021. MATERIALS AND METHODS: The study presents an analysis of data in the Krasnoyarsk Territory from 2011 to 2021. Data processing was carried out using Microsoft Excel and Statistica 6.0 software products. The correlation between morbidity and mortality was assessed using Spearmans correlation analysis, and the result was considered statistically significant at a significance level of p 0.05. RESULTS: An analysis of the incidence of breast cancer in the Krasnoyarsk Territory from 2011 to 2021 showed an increase in the number of cases by 35.2%. The peak incidence falls on the age range of 5569 years. The mortality rate for the study period tends to decrease; 1-year mortality decreased from 9.3% to 5.1%. The level of early diagnosis increased to 76.4%, while the rate of advanced forms of breast cancer decreased from 33.5% to 23.6%. There is an increase in the number of patients with breast cancer, registered in the dispensary for 5 years or more, from 54.7% to 62.7%, due to the use of modern clinical recommendations, the use of long courses of adjuvant endocrine therapy (up to 10 years), a wide range and frequency of use of antitumor, including targeted drugs. Correlation analysis between morbidity and mortality rates for the Krasnoyarsk Territory revealed an average, moderate relationship the correlation coefficient (r=0.59; p 0.05). A direct average correlation was obtained between the proportion of newly diagnosed cases of breast cancer at stages III and IV and the 1-year mortality rate (r=0.64; p 0.05). A very strong relationship was found between newly diagnosed cases of breast cancer and diseases detected at early stages (r=0.97; p 0.05). CONCLUSION: The results obtained indicate the effectiveness of ongoing measures for the prevention and early detection of diseases.

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Background: Anthropometry is one of the simplest and most accessible methods. Breast cancer is largely associated with anthropometric indicators, such as weight, body mass index, waist-to-hip ratio, and waist circumference. Aims: To examine the anthropometric and topometric characteristics of the mammary glands of patients with breast cancer. Materials and Methods: A total of 260 patients with breast cancer were examined from 2019 to 2021 in the Department of Onco-mammological Surgery of the A.I. Kryzhanovsky Krasnoyarsk Regional Oncological Dispensary. Anthropometric examination was conducted according to the classical method, and parameters such as height and weight were obtained. Organometric measurements were conducted according to the Body Logic System (Mentor Medical Systems B. V., USA), developed by Professor Dr. Hammond for Mentor, a silicone implant manufacturer. Results: In the study group, the average height, weight, and body mass index were 163 (158168) cm, 75 (6586) kg, and 28.96 (2432.87) kg/m2, respectively. A comparative analysis of the main anthropometric data of patients with breast cancer showed relatively higher body length values in the young adult group and conversely smaller values in women in the senile period, as well as the average body mass index and body mass index in the older group. In women, the average chest circumference of the mammary gland in the middle-aged group decreased by 9 cm in the older period and by 6 cm in the senile period. Similar changes were found in the chest circumference at the level of the nipples. In women, the average values in the middle-aged group decreased by 9.5 cm in the older period and by 4 cm in the senile period. The distance from the jugular notch to the nipple of the right breast showed significantly (p 0.05) higher values in the older group (by 6 cm) and senile group (by 4.7 cm) than in the young adult group and between the middle-aged group and older group (by 4 cm) and in the senile (by 2.7 cm) group. Similar changes were found on the left breast in the older group (by 5.75 cm) and senile group (by 5.25 cm) compared with young adult group and between the middle-aged group and older group (by 4 cm) and senile (by 3.5 cm) group. The distance from the level of the middle of the clavicle to the nipples showed significantly (p 0.05) lower values of the right and left mammary glands in the your adult group than in other age groups. The intermammary distance was significantly (p 0.05) greater in the middle-aged group (by 0.5 cm) than in the older and senile groups. Conclusion: Most studies on breast anthropometry focus on plastic surgery because clear anthropometric measurements of the breasts and their relative positions based on fixed skeletal and soft tissue landmarks are useful for assessing the condition of the patients preoperatively and for evaluating breast aesthetics postoperatively. Future studies in clinical practice should identify women with a high risk of breast cancer based on anthropometric parameters.

Background. The neutrophil to lymphocyte ratio (NLR) is a prognostic marker in various carcinomas, including breast cancer. The NLR reflects the balance of systemic immunity and is associated with survival in patients with solid tumors.Aim. This study retrospectively evaluated the significance of the NLR and the absolute lymphocyte count in patients with breast cancer who received eribulin therapy.Materials and methods. The prognostic significance of the NLR and the absolute lymphocyte count in 33 patients with metastatic breast cancer treated with eribulin in 2020–2021 was analyzed.Results. The median follow-up time for patients was 9 [6; 15] months. Twenty-six of 33 (78.8 %) patients progressed. Seven of 33 (21.2 %) patients were censored due to therapy discontinuation, complete discontinuation after 1 course was required in 3 (9.1 %) patients and was associated with the development of hematological toxicity: 1 (3 %) case of a combination of grade 3 leucopenia and grade 3 thrombocytopenia, 2 (6 %) cases of grade 3 neutropenia. According to the analysis results, the NLR was a statistically significant risk factor for progression in patients on eribulin therapy, both without taking into account the influence of other factors (univariate model) and with the underlying influence of the absolute neutrophil count and the absolute lymphocyte count: hazard ratio (95 % confidence interval) was 1.21 [1.04; 1.41], p = 0.015 and 1.30 [1.07; 1.57], p = 0.008, respectively. There was no statistically significant effect of the absolute neutrophil count and the absolute lymphocyte count in both univariate and multivariate models. To illustrate the impact of SNL on the onset of progression, patients were divided into two subgroups based on median SNL: SNL˂ 2.46 and SNL ≥2.46. The median survival in patients with SNL ≥2.46 was 9 months, and in patients with SNL˂ 2.46 it was 15 months.Conclusion. The results of the pilot study state the NLR is a potential prognostic marker of long-term treatment with eribulin for patients with metastatic breast cancer, and can be used in clinical practice.