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Summary An extensive series of experiments designed to establish the practicality of combining formaldehyde inactivation with ultraviolet irradiation as a method for the inactivation of poliomyelitis virus for the production of vaccines has been reviewed. The actual use of the combination method is illustrated by safety, stability and potency test data obtained in a series of experimental vaccines. These vaccines were also subjected to trial in humans. The objective has been to introduce and illustrate the feasibility of producing virus vaccines according to standards (11), particularly poliomyelitis, by the use of a combination of chemical (formaldehyde) and physical (ultraviolet) methods of inactivation.

Summary The antibody responses of hospital staff volunteers to polyvalent influenza vaccines containing either intact virus or SPEE virus antigens were compared. Significant increases in HI antibody against each virus strain in both vaccines were observed. Furthermore, postvaccination antibody titers against three of the four strains were significantly greater in the group receiving the SPEE antigens than were those in the group given intact virus. Evidence that the SPEE antigens may be more efficient antibody stimulators than their intact counterparts is presented and discussed.