Objectives: To assess patients with recurrent high grade brain glioma with the aim of evaluating facets of quality of life (QOL) and their association with mood, cognition, and physical performance. Methods: Ninety four glioma patients (four groups with different duration of glioma recurrence) were compared with 24 patients with other chronic neurological diseases and 48 healthy subjects. The Functional Living Index-Cancer (FLIC) provided QOL self evaluations, and standardised scales and neuropsychological tests assessed physical performance, mood, and cognition. Results: In glioma patients, factor analysis of the FLIC items documented five domains: Psychological well being, Role/sociability, Inner experience of disease, Isolation/sharing, and Nausea. Higher FLIC total scores were related to better cognition, physical performances, and mood, and lower grading; poorer Psychological well being and worse Inner experience of disease to depressed mood; minor Role/ sociability to worse cognitive and physical performances and higher grading; worse Nausea to longer disease duration. Compared with healthy subjects, all glioma groups were cognitively impaired and more anxious, and two groups with short duration of recurrence were also more depressed. Patients with chronic neurological diseases showed worse mood and cognitive abilities compared with healthy subjects, but performed attention tests better than glioma patients. Glioma and chronic disease patients showed similar FLIC scores and autonomy. Conclusions: These results show that QOL of recurrent high grade glioma patients is multifaceted and determined by multiple factors. Disease severity does not necessarily eliminate the possibility of expressing personal feelings and opinions which could provide criteria for clinical decision making and psychological support.

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Bekanntlich bildet sich bei der Mehrzahl der weiblichen Säuger mit Erlangung der Geschlechtsreife jener charakteristische Rhythmus der Eierstockfunktion aus, der die ganze Zeit des fortpflanzungsfähigen Alters fortdauert.Dieser Rhythmus wird nur unterbrochen, wenn eine Schwängerung eintritt, die ihrerseits einen neuen Zustand der Eierstockfunktion, nämlich den der Milchabsonderung, vorbereitet.Das heißt, daß der Eierstock während des geschlechtsreifen Alters und außerhalb der physiologischen Unterbrechungen durch Schwangerschaft und Stillen, den für jede Art eigenen Rhythmus seiner Tätigkeit bewahrt.

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