[1,4]Benzodioxanylmethyl-, [1,4]benzodioxanylmethylaminopropyl- and phenoxyethylaminoethyl-substituted lactams were synthesised and their hypotensive activity was investigated. Some of these compounds show moderate to high hypotensive effect, but they had more toxic and/or side effects than GYKI-12 743.

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Seventy‐five title compounds are synthesized and tested for positive inotropic activity.

Synthesis and Hypotensive Activity of Some Heterocyclic Analogues of GYKI-12 743.-The title compounds (III) show moderate to high hypotensive activity whereas compound (VI) does not reduce blood pressure at all. However, ( III) have more toxic side effects than known compounds. -(MATYUS, P.; KASZTREINER, E.; DIESLER, E.; BEHR, A.; VARGA, I.; KOSARY, J.; RABLOCZKY, G.; JASZLITS, L.; Arch. Pharm. (Weinheim, Ger.) 327 (1994) 9, 543-546; Inst. Drug Res., H-1325 Budapest, Hung.; EN)