No abstract

The upper respiratory tract is one of the most important biotopes in the human body. Therefore, in order to understand the cause-effect relationships between the microbial world and the pathological state of a person, it is crucial to clarify the relationship of the microbes-associates.The study involved 74 women with reproductive disorders. The main group – women with chronic endometritis (n = 47). The diagnosis of chronic endometritis was revealed on the basis of morphological signs of histological examination of aspirates from the uterine cavity. The comparison group consisted of 27 women, in whom the chronic endometritis was not confirmed. When applying, women complained more often of infertility and (or) miscarriage. Of the accompanying extragenital diseases, chronic tonsillitis in women of the studied groups was most often diagnosed. Therefore, it was important to give a microbiological description of the nasopharyngeal biotope of these women, as one of the factors that influences the reserves of confrontation of the reproductive function of the body to infections. Nasopharyngeal microbiocenosis of women with chronic endometritis was characterized by deficiency of the indigenous microbiota and a permanent presence in the microbiocenosis of the absolute pathogen (S. aureus) and transient species (enterococci, CNS). Between the representatives of normoflora antagonistic relations were established. The obtained results indicate violations in the nasopharyngeal biotope of these women, which can cause immunodeficiency and, as a consequence, the development and flow of chronic endometritis.

На современном этапе исследований не подверга-ется сомнению тот факт, что микробиота кишечника человека не только играет значительную роль поддер-жании здоровья, но и вносит значительный вклад в развитие многих заболеваний. Нарушение качествен-ного и количественного соотношения микрофлоры кишечника (дисбиоз) возникает от разнообразных причин, развивается задолго до клинических про-явлений и служит предвестниками более глубоких отклонений на уровне целостного организма.В ряде исследований показано, что изменение пейзажа кишечной микробиоты оказывает влияние на течение таких заболеваний, как синдром раздра-жённого кишечника (СРК), неспецифический язвен-ный колит (болезнь Крона), сахарный диабет 1-го и 2-го типов, ожирение [4,12,13].

CHARACTERISTICS OF THE MICROBIOCENOSIS OF THE VAGINAL TRACT AND ITS ROLE IN INITIATING INFLAMMATORY PROCESS IN ENDOMETRIUM IN WOMEN WITH REPRODUCTIVE DISORDERS