0 1 7 ) A 3 9 9 -A 8 1 1 A717 objective of this study was to perform a systematic review of the most recent literature to better understand the efficacy and safety of current treatment for women with PPD. Methods: A systematic review of Medline, Embase, PsychInfo, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and several congresses was conducted according to the PRISMA Statement through February 2017 to identify literature on the treatment of PPD. Disease search terms included "postpartum depression", "postnatal depression", and "peripartum depression". Inclusion criteria included women with PPD aged ≥ 15 years treated in observational or interventional studies with any pharmacologic therapy. Results: In total, 889 unique studies were screened by two independent researchers by title and abstract; of these 58 full-text studies were evaluated and 31 were included in this review. In general, evidence supporting the efficacy of pharmacological therapies is limited; in particular, 3 placebo-controlled studies of 303 total patients did not report statistically significant improvements in various depression symptoms scores for nortriptyline or sertraline. In another study of 70 patients with PPD who were randomized to paroxetine or placebo, statistically significant improvements of pharmacologic therapy over placebo were shown for certain outcomes (e.g., proportion achieving remission by week 8, 37% vs. 15%; p = 0.04), whereas other measures of efficacy had borderline or non-significant differences between groups. Overall, evidence supporting the treatment of women with PPD is limited and complicated by variability in the study design and methods used to assess symptoms. ConClusions: Several treatments in women with PPD have been studied; however, evidence supporting the efficacy of these therapies is limited.

A LT H 1 7 ( 2 0 1 4 ) A 7 1 9 -A 8 1 3 reasons for self-medication, factors that influenced the choice of drug and source of drug. Results: People of all socio-demographic categories practice self-medication. A total of 76.8% of the respondents indulged in self-medication practices. Of which, 33.0% used the medication inappropriately. The most frequently self-diagnosed illnesses or symptoms of illnesses were: GI illnesses, cough/cold and headache/fever. Of these illnesses, more than 35% were less than 24 hours duration and nearly 80% less than seven days duration of illness. The reasons given by respondents for selfdiagnosis and self-medication were non-seriousness of the illnesses, for emergency use and prior experience about the illness with similar symptoms (39.7%) and even advice of non-physician health professional (33.5%). Whatever the duration of illnesses and reasons for self-diagnosis, nearly 65% requested drugs by mentioning the names of the drugs and more than one-fifth by telling the symptoms of their illnesses. Requests for analgesics/antipyretics were very high (60%) followed by antimicrobial drugs (40%) for all reported illness. Drug requested mostly in other conditions include cold/cough suppressants, Gastro Intestinal drugs and very low for ORS. ConClusions: The level of inappropriate drug use denotes self-medication as an unhealthy option, and it therefore, should be discouraged.

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Background The CEBCPGs produces CPGs on high priority health topics to establish recommendations based on best evidence. The authors summarise the main methods used in adaptation and implementation of these CPGs. Objectives The aim of this work was to promote simplicity, avoid redundancy and decrease delay in the process of CPG adaptation. Methods Part 1) Cross-sectional/ or retrospective study and assessment of the current situation of practice in selected healthcare settings to identify/select high priority health topic(s) and to justify the need for producing a CPG for this topic(s) and expected benefit and outcome for its implementation; Part 2) consists of the Methodology for CPGs adaptation, based on an adaptation of The ADAPTE Process developed by the ADAPTE Collaboration. Results Three main ADAPTE steps were identified as cornerstones of the process and another two steps in the assessment module were replaced by the AGREE Domains scores. Implications for Guideline Developers/Adapters/Users 1. Health Topics for CPG Adaptation & Implementation should be selected based on Cross-sectional study/surveys for local Healthcare Professionals. 2. Adaptation of CPGs as a valid alternative to de novo development has many benefits for resource utilisation and unifying practice. 3. The ADAPTE process is that it is adaptable to local context and resources. 3. Successful CPGs Implementation Strategies; i)For Practitioners: Implementation tools designed to facilitate behavioural/practice changes (e.g. Methods A document search on website and database of responsible organisations for material on current development procedures. Scoping literature search on opinion papers on the use of research on patient preferences in CPG development and coverage decisions (HTA). Selected CPG and coverage decisions were checked. Results Procedures for coverage decisions do not mention the search for or use of research on patient preferences, nor was information found in the coverage case studies. In CPG development procedure a mandatory (Scotland) or optional (Netherlands) search for studies that reflect patients' experiences and preferences is described. The CPG case studies show various use of patient preferences in different conceptualisations. Discussion In coverage decisions research on patient preferences has no formal role yet. In CPG this role is limited. Integration of research on patient preferences is hampered by several factors. Implications for Guideline Developers/Users Directions for the future include: 1) conceptual work on defining and measuring patient preferences; 2) reaching consensus on the value and place of research on patient preferences for and in procedures and 3) developing a strategy for integration in procedures. Background Diagnostic imaging (DI) is used several ways in patient management, and the evidence required for each of these roles is somewhat different. This presentation will focus on the evidence needed to develop guidelines for the use of DI in primary diagnosis. Context GRADE states that randomise...