The aim of the work was to determine and compare the structure of microorganisms isolated from bronchoalveolar lavage from patients in the ICU of Clinics in 2016 and 2019. This work presents the results of a bacteriological examination of 229 samples from 139 patients for 2016 and 387 samples from 218 patients for 2019. The predominant microorganism in 2016 was Acinetobacter baumanii - 75 (26.2%). Less common were Klebsiella pneumoniae - 55 (19.2%), Pseudomonas aeruginosa - 35 (12.2%), Escherichia coli - 19 (6.6%). In 2019, the prevailing microorganism was K.pneumoniae - 158 (19.1%). As in 2016, A.baumanii - 115 (13.9%) and P. aeruginosa - 57 (6.9%) were most often found, but unlike 2016, in 2019 there was a high incidence of such pathogens as Enterococcus faecalis - 52 (6.3%), Candida albicans - 43 (5.2%), Staphylococcus aureus and Stenotrophomonas maltophilia - 40 (4.8%). One of the features is the presence of polymicrobial associations. In 2016, microorganisms isolated in monoculture predominated (53.4%), while in 2019 the frequency of occurrence of monocultures decreased and amounted to 24.7%. At the same time, a two-component association prevailed (31.5%). Thus, in ICU it is necessary to regularly monitor nosocomial pathogens not only to make the right decision when choosing antimicrobial therapy, but also to identify new potential nosocomial pathogens.

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The article presents a clinical case of a patient of the otorhinolaryngology department of the Samara Clinical Hospital No. 8 who had a new coronavirus infection. Complications were manifested by primary thrombosis of the orbital veins, facial veins, followed by the spread of the process into the pterygoid plexus, veins of the nasal cavity and paranasal sinuses. The study analyzes the dynamics of the clinical picture and compares it with the results of the postmortem examination. Vascular thrombosis of the nasal cavity and paranasal sinuses during X-ray examination can manifest itself as a decrease in pneumatization of the sinuses with possible minor exudation due to ischemic changes in the mucous membrane. Thrombosis developing with underlying COVID-19-associated coagulopathy can have different initial localizations and are a formidable complication with a high mortality rate. Patients who have undergone COVID-19 need to control the coagulogram not only during the illness, but also during the period of convalescence and early periods after recovery.