The combination of continuous infusion of carboplatin and radiotherapy at the aforementioned doses in patients with locally advanced cervical carcinoma resulted in a relatively low frequency of significant acute and late complications. Platinum in normal tissue (picograms per lymphocyte) was stable from week 1 of treatment, whereas the platinum steady state in plasma and in tumor cells was not reached in 6 weeks and was below that required in vitro to produce radiopotentiation. Further studies to determine the optimal dose of carboplatin and irradiation are needed prior to the initiation of phase-III studies.

A retrospective analysis of a series of 162 patients treated for isolated chest wall recurrence of breast cancer after mastectomy was undertaken. Cumulative survival, distant relapse-free survival, and freedom from local progression after 5 years from the diagnosis of recurrence were 34%, 28%, and 45% respectively. Five prognostic factors influenced survival: axillary node status, primary T stage, length of disease-free interval, and number and size of recurrences. Four prognostic factors influenced the local control: axillary node status, primary T stage, disease-free interval, and number of recurrences. Patients with three or more, out of five, favorable prognostic factors fared much better than those with two or less: 75% versus 15% survival at 5 years. Our findings suggest that it is possible to identify a group of patients with a distinctly good medium-term survival and local control of disease.Cancer 60:240-244, 1987. HE REPORTED INCIDENCE of locoregional recur-T rence of breast cancer following radical surgery ranges from 10% to 20%.'s2 Different selection criteria for radical mastectomy and heterogeneity in adjuvant treatment programs may account for an even wider variability. Several studies have dealt with prognosis and treatment of locally recurrent breast ~a n c e r ,~-'~ but in some of them a separate analysis of local ( k , on chest wall) and regional (i. e., in lymphatic areas) recurrences has not been performed. Although a consensus opinion regarding the treatment of local relapse does not exist, aggressive rather than palliative therapeutic approaches have been supported by most authors as an attempt to achieve local control and to improve survival.In the current study 162 patients treated for isolated chest wall recurrences in two radiotherapy centers were evaluated retrospectively. This study was undertaken to assess the relationship to local control and survival from time of recurrence of various clinical factors, which were tested for prognostic significance. We also tried to identify groups of patients with a distinctly different risk of local progression and/or death since the occurrence of relapse, with the aim of being able, in the future, to adopt different treatment programs in high and low risk groups.From the *Istituto del Radio 0. Alberti, Brescia, Italy, and tDiviAddress for reprints: Lorenzo Magno, MD, Istituto del Radio 0.The authors thank Claudio Parmigiani for his help with statistics.

The short course of brachytherapy provides a good palliation in terms of functional improvement in a high proportion of patients, with low and acceptable toxicity.

Our approach seems to be of some interest for the palliation of GBL, and it offers some advantages, in particular regarding the short treatment period. Our procedure can be improved: a multi-catheter implant and a more fractionated schedule could be taken into account.

The authors, by analysing 31 cylindromas and 65 squamous cell carcinomas of the maxillary sinus, reached the conclusion that at a T2–T3, identical stage of development and with similar treatment, the carcinoma has a worse prognosis than the cylindroma, the latter being influenced in its clinical evolution by its histologic characteristics. In particular, the solid cellular pattern negatively affects the survival period.